Organic Letters
Letter
Notes
(14) Martis, A.; Luridiana, A.; Frongia, A.; Arca, M.; Sarais, G.; Aitken,
D. J.; Guillot, R.; Secci, F. Org. Biomol. Chem. 2017, 15, 10053.
The authors declare no competing financial interest.
(
16) When phenol 3b was reacted with 1a, under the operational
reaction conditions we observed the formation of a solid side product
ACKNOWLEDGMENTS
■
(
This work was partially supported by the Fondazione di
Sardegna under the project “Innovative antioxidant molecules
for the food and health industry” (CUP F71I17000180002).
The authors gratefully acknowledge R.A.S. “Sardinia Regional
Government” (FIR 2017). C.I.N.M.P.I.S. (Consorzio Inter-
universitario Nazionale di Ricerca in Metodologie e Processi
Innovativi di Sintesi) is also acknowledged.
3
b′ (8% yield), which was characterized by X-ray diffractometric
(17) (a) Hallmann, G.; Hagele, K. Leibigs. Ann. Chem. 1963, 662, 147.
(
b) Pinder, R. M.; Green, D. M.; Thompson, P. B. J. Med. Chem. 1971,
4, 626. (c) Kedrowski, S. M. A.; Bower, K. S.; Dougherty, D. A. Org.
Lett. 2007, 9, 3205.
18) 1-(Biphenyl-2-yl)piperazine was synthesized as described in the
1
(
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Org. Lett. XXXX, XXX, XXX−XXX