141283-42-3

Basic information

• Product Name: 8-Nitro-2-tetrazol-5-yl-4-oxo-4H-1-benzopyran
• Synonyms: 8-Nitro-2-tetrazol-5-yl-4-oxo-4H-1-benzopyran;8-Nitro-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-4-one
• CAS NO: 141283-42-3
• Molecular Formula: C10H5N5O4
• Molecular Weight: 259.1778
• Mol File: 141283-42-3.mol

Chemical Properties

• Boiling Point: 508.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.738
• PKA: 4.82±0.10(Predicted)
• CAS DataBase Reference: 8-Nitro-2-tetrazol-5-yl-4-oxo-4H-1-benzopyran(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Nitro-2-tetrazol-5-yl-4-oxo-4H-1-benzopyran(141283-42-3)
• EPA Substance Registry System: 8-Nitro-2-tetrazol-5-yl-4-oxo-4H-1-benzopyran(141283-42-3)

Safety Data

• Hazardous Substances Data: 141283-42-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
8-Nitro-2-tetrazol-5-yl-4-oxo-4H-1-benzopyran is used as a potential antithrombotic and antiplatelet agent for its ability to influence blood clotting and platelet aggregation, which are critical factors in the treatment and prevention of cardiovascular diseases.
Used in Materials Science:
In the field of materials science, 8-Nitro-2-tetrazol-5-yl-4-oxo-4H-1-benzopyran is used as a component in the development of luminescent materials, leveraging its photophysical properties to create materials that emit light under certain conditions, which can be applied in various technological and industrial applications.

Upstream product

• 134138-87-7 2-carboethoxy-7-(4-(quinolin-2-yl-methoxy)phenoxymethyl)-4-oxo-4H-1-benzopyran 
• 141283-41-2 8-nitro-4-oxo-4H-1-benzopyran-2-carbonitrile 
• 110683-75-5 ethyl 8-nitro-4-oxo-4H-benzopyran-2-carboxylate 
• 161369-34-2 8-nitro-4-oxo-4H-1-benzopyran-2-carboxamide 

Downstream Products

• 110683-22-2 8-amino-4-oxo-2-(5-1H-tetrazolyl)-4H-1-benzopyran 
• 110683-23-3 8-amino-4-oxo-2-tetrazol-5-yl-4H-1-benzopyran hydrochloride 

Relevant articles and documents

Benzopyran derivatives having leukotriene-antagonistic action

The present invention relates to novel 4-oxo-4H-1-benzopyran compounds containing benzyloxymethyl, 3-phenylpropyl, or other araliphatic substituents in their 8-position. These compounds show a leukotriene-antagonistic activity. The compounds are characterized by good oral adsorption. The compounds of the present invention may be used as anti-inflammatory and antiallergic medicaments, and in the treatment of cardiovascular diseases.

QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4

This invention relates to certain quinolinyl-benzopyran compounds and their use as valuable pharmaceutical agents, particularly as lipoxygenase inhibitors and/or leukotriene antagonists and/or mediator release inhibitors possessing anti-inflammatory and anti-allergic properties.

QUINOLINYL-CHROMONE DERIVATIVES AND USE FOR TREATMENT OF HYPERSENSITIVE AILMENTS

This invention relates to certain quinolinyl-chromone compounds and their use as valuable pharmaceutical agents, particularly as lipoxygenase inhibitors and/or leukotriene antagonists possessing anti-inflammatory and anti-allergic properties.

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.