Aromatic borylation/amidation/oxidation: A rapid route to 5-substituted 3-amidophenols
5-Substituted 3-amidophenols are prepared by subjecting 3-substituted halobenzenes to an Ir-catalyzed aromatic borylation, followed by a Pd-catalyzed amidation, and finally an oxidation of the boronic ester intermediate. The entire C-H activation borylation/amidation/oxidation sequence can be accomplished without isolation of any intermediate arenes. Usefully, amide partners can include lactams, carbamates, and ureas.
Shi, Feng,Smith III, Milton R.,Maleczka Jr., Robert E.
Synthesis of the N-acetylcysteamine thioester of seco-proansamitocin
(Chemical Equation Presented) The enantioselective total synthesis of the N-acetylcysteamine thioester of seco-proansamitocin, a key biosynthetic intermediate of the highly potent antitumor agent ansamitocin, is described, which twice utilizes the Nagao a
Frenzel, Thomas,Bruenjes, Marco,Quitschalle, Monika,Kirschning, Andreas
p. 135 - 138
(2007/10/03)
More Articles about upstream products of 141311-38-8