141484-09-5

Basic information

• Product Name: 3-Cyclohexen-1-amine, 4-methyl-, (R)-
• CAS NO: 141484-09-5
• Molecular Formula: C7H13N
• Molecular Weight: 111.187
• Mol File: 141484-09-5.mol

Chemical Properties

• CAS DataBase Reference: 3-Cyclohexen-1-amine, 4-methyl-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyclohexen-1-amine, 4-methyl-, (R)-(141484-09-5)
• EPA Substance Registry System: 3-Cyclohexen-1-amine, 4-methyl-, (R)-(141484-09-5)

Safety Data

• Hazardous Substances Data: 141484-09-5(Hazardous Substances Data)

Upstream product

• 141484-08-4 (1R)-1-azido-4-methyl-3-cyclohexene 
• 203719-53-3 (-)-limonene oxide 
• 141484-07-3 (-)-(1S)-4-methyl-3-cyclohexen-1-yl 4-methylbenzenesulfonate 
• 141483-99-0 (+)-(1R)-4-methyl-3-cyclohexen-1-yl 4-methylbenzenesulfonate 
• 73041-84-6 (4S)-1-methyl-4-acetoxycyclohexane 1,2-oxide 
• 351184-36-6 (4R)-1-methyl-4-acetoxycyclohexane 1,2-oxide 
• 141484-06-2 (-)-(1S)-4-methyl-1-acetoxy-3-cyclohexene 
• 141483-97-8 (+)-(1R)-4-methyl-1-acetoxy-3-cyclohexene 
• 141483-98-9 (+)-(1R)-4-methyl-3-cyclohexen-1-ol 
• 203508-62-7 1-(3S)-(6-methyl-7-oxabicyclo[4.1.0]heptan-3-yl)ethanone 
• 93915-81-2 (-)-(1S)-4-methyl-3-cyclohexen-1-ol 
• 5989-54-8 (-)-(S)-limonene 

Downstream Products

• 141484-10-8 (-)-(1R)-N,4-dimethyl-3-cyclohexenamine 
• 141484-13-1 (+)-(1R)-N,4-dimethyl-N-(4-methyl-3-pentenyl)-3-cyclohexenamine 
• 141484-12-0 (+)-(1R)-N,4-dimethyl-N-(4-methyl-3-cyclohexenyl)-3-pentenamide 
• 1403864-98-1 (1R,2R,5R)-5-amino-2-methylcyclohexan-1-ol hydrochloride 
• 1403864-94-7 tert-butyl ((1R,3R,4R)-3-hydroxy-4-methylcyclohexyl)carbamate 
• 1403859-14-2 2-(tert-butylamino)-4-{[(1R,3R,4R)-3-hydroxy-4-methylcyclohexyl]amino}pyrimidine-5-carboxamide 
• 141484-16-4 (+)-(1R)-1-methyl (4-methyl-3-cyclohexenyl)carbamate 

Relevant articles and documents

SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE

Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE

Provided herein are formulations, processes, solid forms and methods of use relating to 2- (tert-butylamino)-4-((lR,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5- carboxamide.

Trichodiene Synthase. Synergistic Inhibition by Inorganic Pyrophosphate and Aza Analogs of the Bisabolyl Cation

A series of aza analogs of the bisabolyl and α-terpinyl cations were tested as inhibitors of the sesquiterpene cyclase, trichodiene synthase.Both (R)- and (S)-16 and (R)- and (S)-13 as well as trimethylamine were only weak inhibitors when incubated alone.In the presence of inorganic pyrophosphate, itself a known competitive inhibitor of trichodiene synthase, all five amines showed strong cooperative competitive inhibition with an enhancement factor estimated to be 10-40.The apparent induced inhibition constant αKJ decreased in going from trimethylamine to the monoterpene analogs 13 and was strongest for the sesquiterpene analogs 16, indicating that both electrostatic and hydrophobic interactions are important in the binding of each intermediate analog.The cyclase showed little discrimination, however, between the individual enantiomers of each inhibitor.