5989-54-8 Usage
Description
Different sources of media describe the Description of 5989-54-8 differently. You can refer to the following data:
1. (S)-(-)-Limonene is one of the most popular natural occurring cyclic terpenes and its chemical name is D-Limonene. It is a colorless liquid at room temperature with a characteristic lemon-like odor. Although it is insoluble in ether and alcohol, (S)-(-)-Limonene is soluble in water and has a boiling point of 74oC. (S)-(-)-Limonene can be recovered from orange peel from the conversion of press liquor to molasses. It is a major constituent of numerous citrus oils such as lemon, orange, lime, mandarin, and grapefruit, which are fruits from the Rutaceae family.
(S)-(-)-Limonene can be obtained by stream distillation of pulp and citrus peels resulting from production of cold-pressed oils and juice or from deterpenation of citrus oils. The compound also occurs in other essences and oils obtained during the processing of citrus juice, including deoiler, essence oil, aroma, and juice oil.
2. ι-Limonene has a pleasant, lemon-like odor free from camphora ceous and turpentine-like notes. The most important and wide spread terpene; it is known in the d- and ι- optically active forms
and in the optically inactive dl-form (known as dipentene); it has
been reported found in more than 300 essential oils in amounts
ranging from 90 - 95% (lemon, orange, mandarin) to as low as 1% (palmarosa);1 the most widespread form is the d-limonene,
followed by the racemic form, and then ι-limonene.
Chemical Composition and Reactions
The main D-Limonene’s compositions include camphene, a-pinene, a-terpene, b-pinene, b-bisabolene, trans-a-bergamotene, limonene, neral, and nerol. It chemically belongs to the family of cycloalkane known as terpenes. Notably, its IUPAC name is 4-isopropeny–1–methylcyclohexane.
D-limonene can be distilled without decomposing and is a typically stable monoterpene, but can crack in high temperatures to form isoprene. D-limonene oxidizes easily in moist air to generate limonene oxide, carvone, and carveol. It dehydrates when reacted with Sulphur to form p-cymene. D-limonene isomerizes to conjugated diene α-terpinene when heated with mineral acid.
Application
Clinical Applications
As an excellent cholesterol solvent, (S)-(-)-Limonene is normally used clinically to dissolve cholesterol containing gallstones.
It has also been used for relieving of heartburn and gastroesophageal reflux disorder (GERD) due to its gastric acid neutralizing characteristic and its support for normal peristalsis.
Studies have established (S)-(-)-Limonene’s chemo-preventive activity against many types of cancers. Patients with breast cancer showed partial response while patients with colorectal cancer were stable for more than six months from phase 1 clinical trials.
D-limonene is also used in maintaining regular bowel movements, particularly when slow movements are caused by a fungus known as Candida albicans that normally lead cause intestinal infection.
D-limonene is used as a mild suppressor of appetite, thus it can be employed to help in managing weight. Notably, it is useful when an individual has unhealthy blood sugar levels.
Personal Use
D-limonene is used as flavoring agent to mask the bitter taste of alkaloids as well as a fragrance in perfumery. The compound is also used in bath products, aftershave lotions as well as other personal products. It is normally added to cleaning products, for instance, hand wash solutions to give an orange or lemon fragrance.
Food Industry
D-limonene is used as a fragrance and flavoring in the manufacture of foods, chewing gums, and beverages.
Agricultural Use
D-limonene is utilized as botanical insecticide as well as in the organic herbicide “Aenger.”
Industrial Purposes
Since it is produced from naturally from citrus oil and byproducts during manufacturing of orange juice, d-Limonene is used as solvent for cleaning purposes, for example, the removal of oil from parts of machines.
It is also used as a paint stripper as well as an alternative fragrance to turpentine. In some airplane models, d-Limonene is used as a solvent in glues and as a constituent in some paints. The compound is also used in commercial air fresheners. It is also used to remove self-adhesive postage stamps from envelopes by philatelists.
d-Limonene has been considered as a biofuel due to its combustibility.
Printing
D-Limonene is used as a solvent for filament that is used in 3D printing. Printers are able to erect binders and supports from HIPS, which is a polystyrene plastic that can easily dissolve in d-Limonene.
Therapeutic
The therapeutic properties of d-limonene include antimicrobial, antianaemic, antiseptic, and anti-sclerotic. The compound also has carminative, bactericidal, depurative, cicatrizant, diuretic, rubefacient, hyposensitive, vermifuge, and tonic characteristics.
Histology
D-Limonene is often used in preparing tissues (especially when cleaning dehydrated specimen) for histology due to its less toxic characteristic as compared to xylene.
Others
D-limonene is used on wounds and sores, aromatherapy, douching, cataract, foots, mouth ulcers, varicose, and spots.
Safety and Side Effects
D-limonene is considered to have low toxicity; therefore, does not pose a carcinogenic, mutagenic, or nephrotoxic risk to humans. In proportional food amounts, d-limonene is safe. When taken orally for up to one year in correct medical amounts, d-limonene appears safe for most people.
However, there is no enough information or research regarding the effect of d-limonene on pregnant and breast feeding women when taken in larger medical amounts. As such, it is vital to stay on the safer side until more research is done.
Dosing
The correct dosage for d-limonene is dependent on numerous factors, such as user’s health, age, as well as other conditions. It is important to note that natural products are not necessarily safe, thus dosage can be important.
Chemical Properties
colourless liquid with lemon odour
Uses
(S)-(-)-Limonene is used to inhibit the proliferation of colon cancer cells. It is also used in artificial essential oils in order to produce (+)-carvone. It is an active component of turpentine. Further, it is used in flavorings, fragrances, and cosmetics. It finds application as a solvent and wetting agent. In addition to this it is used to produce resins.
Definition
ChEBI: An optically active form of limonene having (4S)-configuration.
General Description
(S)-(-)-Limonene, a monoterpenoid compound, is mostly used in perfumery and in flavoring. On irradiation, it undergoes radiolysis, which leads to a reduction in the optical purity. (S)-(-)-Limonene also shows potent antimicrobial activity.
Flammability and Explosibility
Flammable
Contact allergens
Limonene is a racemic form of dand l-limonene.
d-Limonene is contained in Citrus species such as citrus,
orange, mandarin, and bergamot. l-Limonene is
contained in Pinus pinea.
Safety Profile
A skin irritant. When
heated to decomposition it emits acrid
smoke and irritating fumes.
Check Digit Verification of cas no
The CAS Registry Mumber 5989-54-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,8 and 9 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 5989-54:
(6*5)+(5*9)+(4*8)+(3*9)+(2*5)+(1*4)=148
148 % 10 = 8
So 5989-54-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3
5989-54-8Relevant articles and documents
Electro-mediated PhotoRedox Catalysis for Selective C(sp3)–O Cleavages of Phosphinated Alcohols to Carbanions
Barham, Joshua P.,K?nig, Burkhard,Karl, Tobias A.,Reiter, Sebastian,Tian, Xianhai,Yakubov, Shahboz,de Vivie-Riedle, Regina
supporting information, p. 20817 - 20825 (2021/08/18)
We report a novel example of electro-mediated photoredox catalysis (e-PRC) in the reductive cleavage of C(sp3)?O bonds of phosphinated alcohols to alkyl carbanions. As well as deoxygenations, olefinations are reported which are E-selective and can be made Z-selective in a tandem reduction/photosensitization process where both steps are photoelectrochemically promoted. Spectroscopy, computation, and catalyst structural variations reveal that our new naphthalene monoimide-type catalyst allows for an intimate dispersive precomplexation of its radical anion form with the phosphinate substrate, facilitating a reactivity-determining C(sp3)?O cleavage. Surprisingly and in contrast to previously reported photoexcited radical anion chemistries, our conditions tolerate aryl chlorides/bromides and do not give rise to Birch-type reductions.
Upcycling a plastic cup: One-pot synthesis of lactate containing metal organic frameworks from polylactic acid
Slater, Benjamin,Wong, So-On,Duckworth, Andrew,White, Andrew J. P.,Hill, Matthew R.,Ladewig, Bradley P.
supporting information, p. 7319 - 7322 (2019/06/27)
Waste PLA can be upcycled to metal organic frameworks of potential high value in a one-pot synthesis scheme, where PLA depolymerisation occurs in situ. Three homochiral lactate based frameworks were successfully synthesised and characterised from PLA as a feed source, including ZnBLD. The chiral separation ability of ZnBLD was maintained.
Photocatalytic Transfer Hydrogenolysis of Allylic Alcohols on Pd/TiO2: A Shortcut to (S)-(+)-Lavandulol
Takada, Yuki,Caner, Joaquim,Kaliyamoorthy, Selvam,Naka, Hiroshi,Saito, Susumu
supporting information, p. 18025 - 18032 (2017/12/08)
We report herein a regio- and stereoselective photocatalytic hydrogenolysis of allylic alcohols to form unsaturated hydrocarbons employing a palladium(II)-loaded titanium oxide; the reaction proceeds at room temperature under light irradiation without stoichiometric generation of salt wastes. Olefin and saturated alcohol moieties tolerated the reaction conditions. Hydrogen atoms were selectively incorporated into less sterically congested carbons of the allylic functionalities. This protocol allowed a short-step synthesis of (S)-(+)-lavandulol from (R)-(?)-carvone by avoiding otherwise necessary protection/deprotection steps.
