Nonsteroidal antiinflammatory agents. Part 21: Optically active stereoisomers of p-trifluoromethylphenyl- and p-thioanisyl-biphenylyl-hydroxypropionic acids
The synthesis, diastereomeric separation, assignment to erythro- and threo-configuration by 1HNMR, and optical resolution of 3-(p-trifluoromethyl-phenyl)- and (p-thioanisyl)-2-biphenylyl-3-hydroxypropionic acids are described. The enantiomers were submitted to a preliminary assay to determine antiinflammatory activity.