142138-83-8

Basic information

• Product Name: (2S,3aS,7aS)- octahydro-α,α-diphenyl-1H-Indole-2-Methanol
• Synonyms: (2S,3aS,7aS)- octahydro-α,α-diphenyl-1H-Indole-2-Methanol;(2S,3aS,7aS)-Octahydro-α,α-diphenyl-1H-indole-2- methano;(2S,3aS,7aS)-Octahydro-α,α-diphenyl-1H-indole-2-methanol,99%e.e.
• CAS NO: 142138-83-8
• Molecular Formula: C₂₁H₂₅NO
• Molecular Weight: 307.4293
• Mol File: 142138-83-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S,3aS,7aS)- octahydro-α,α-diphenyl-1H-Indole-2-Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3aS,7aS)- octahydro-α,α-diphenyl-1H-Indole-2-Methanol(142138-83-8)
• EPA Substance Registry System: (2S,3aS,7aS)- octahydro-α,α-diphenyl-1H-Indole-2-Methanol(142138-83-8)

Safety Data

• Hazardous Substances Data: 142138-83-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
(2S,3aS,7aS)octahydro-α,α-diphenyl-1H-Indole-2-Methanol is used as a research compound for the development of medications with potential sedative, analgesic, or antidepressant properties. Its potential effects on the central nervous system make it of interest in the field of neuroscience.
Used in Medications for Various Health Conditions:
(2S,3aS,7aS)octahydro-α,α-diphenyl-1H-Indole-2-Methanol is used as an active pharmaceutical ingredient in the development of new drugs for the treatment of various health conditions, leveraging its potential therapeutic effects.

Upstream product

• 1213770-24-1 (4aS,8aS,9aS)-1,1-diphenyloctahydrooxazolo[3,4-a]indol-3(1H)-one 
• 80875-98-5 (2S,3aS,7aS)-perhydroindole-2-carboxylic acid 
• 1213770-22-9 (2S,3aS,7aS)-1-ethyl 2-methyl hexahydro-1H-indole-1,2(2H,3H)-dicarboxylate 

Downstream Products

• 1213770-27-4 (2S,3aS,7aS)-2-(diphenyl(trimethylsilyloxy)methyl)octahydro-1H-indole 

Relevant articles and documents

Organocatalyzed regioselective and enantioselective synthesis of 1,4- and 1,2-dihydropyridines

Herein, we introduce one of the first examples of asymmetric organocatalyzed synthesis of 1,2-dihydropyridines, affording enantioselective access to and partially solving regioselectivity challenges in the synthesis of dihydropyridines. We demonstrate that through modification of organocatalysts both 1,2- and 1,4-dihydropyridines (1,2- and 1,4-DHPs) can be obtained with high regioselectivity (ratio of 1,2-DHP/1,4-DHP from 95/5 to 0/100) and enantioselectivity (33% ee for 1,2-DHPs and up to 98% ee for 1,4-DHPs) in good yields (up to 87%).

Highly efficient asymmetric michael reaction of aldehydes to nitroalkenes with diphenylperhydroindolinol silyl ethers as organocatalysts

New dihydroindole and perhydroindole derivatives were synthesized in good yields and evaluated as chiral catalysts in the asymmetric Michael reaction of aldehydes to nitroalkenes. (2S,3aS,7aS)Diphenylperhydroindolinol silyl ether 10 facilitated the reacti