142335-61-3

Basic information

• Product Name: 4-(1H-Pyrazol-1-ylmethyl)aniline
• Synonyms: TIMTEC-BB SBB009348;4-(1H-PYRAZOL-1-YLMETHYL)ANILINE;4-PYRAZOL-1-YLMETHYL-PHENYLAMINE;AKOS B014372;ART-CHEM-BB B014372;ART-CHEM-BB B016016;4-Pyrazol-1-ylmethylphenylamine95%;4-PYRAZOL-1-YLMETHYLPHENYLAMINE 95%
• CAS NO: 142335-61-3
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.21
• EINECS: 604-604-1
• Mol File: 142335-61-3.mol

Chemical Properties

• Melting Point: 67-69°C
• Boiling Point: 363.6°C at 760 mmHg
• Flash Point: 173.7°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 1.78E-05mmHg at 25°C
• Refractive Index: 1.622
• PKA: 4.53±0.10(Predicted)
• CAS DataBase Reference: 4-(1H-Pyrazol-1-ylmethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-Pyrazol-1-ylmethyl)aniline(142335-61-3)
• EPA Substance Registry System: 4-(1H-Pyrazol-1-ylmethyl)aniline(142335-61-3)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 142335-61-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-(1H-Pyrazol-1-ylmethyl)aniline serves as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
4-(1H-Pyrazol-1-ylmethyl)aniline is also utilized in the production of agrochemicals, where it plays a crucial role in the synthesis of compounds that can be used in agriculture to protect crops and enhance yields.
Used in Organic Compounds Synthesis:
4-(1H-Pyrazol-1-ylmethyl)aniline is employed in the synthesis of a variety of organic compounds, showcasing its versatility and importance in organic chemistry.
Used in Medicinal Chemistry and Drug Development:
In the field of medicinal chemistry, 4-(1H-Pyrazol-1-ylmethyl)aniline holds potential for the development of new chemical entities with valuable biological properties. Its unique structural features make it a promising candidate for drug discovery and the advancement of pharmaceutical research.
Overall, 4-(1H-Pyrazol-1-ylmethyl)aniline is a versatile and valuable chemical intermediate with applications across multiple industries, including pharmaceuticals, agrochemicals, and organic chemistry, as well as in the broader domain of medicinal chemistry and drug development.

InChI:InChI=1/C10H11N3/c11-10-4-2-9(3-5-10)8-13-7-1-6-12-13/h1-7H,8,11H2

Upstream product

• 100-14-1 4-nitrobenzyl chloride 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 110525-57-0 1-(4-nitrobenzyl)-1H-pyrazole 

Downstream Products

• 80200-09-5 4-((1H-pyrazol-1-yl)methyl)phenol 
• 142335-62-4 2-(4-Pyrazol-1-ylmethyl-phenoxy)-propionic acid ethyl ester 
• 1018443-64-5 3-[(2,5-dichlorophenoxy)methyl]-N-[4-(1H-pyrazol-1-ylmethyl)phenyl]benzamide 
• 1400286-85-2 tert-butyl 6-(4-((1H-pyrazol-1-yl)methyl)phenylamino)-2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 
• 1257651-74-3 N-(4-((1H-pyrazol-1-yl)methyl)phenyl)-2-(1H-indol-3-yl)-2-oxoacetamide 

Relevant articles and documents

HETEROARYL INHIBITORS OF PDE4

The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of disease.

Structure-activity studies on a 1,2,3-triazole derivative, a potent in vitro inhibitor of prostaglandin synthesis: The role of the heterocyclic ring

This paper reports further structural modifications concerning the 1,2,3- triazole ring of the compound A, an effective in vitro inhibitor of prostaglandin synthesis. The introduction of different heterocyclic rings provided further information about of t