142483-57-6

Basic information

• Product Name: methyl 1-(2-ethoxy-2-oxoethyl)pyrrolidine-3-carboxylate
• Synonyms: methyl 1-(2-ethoxy-2-oxoethyl)pyrrolidine-3-carboxylate;3-(Methoxycarbonyl)-1-pyrrolidineacetic acid ethyl ester
• CAS NO: 142483-57-6
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 215
• Mol File: 142483-57-6.mol

Chemical Properties

• Boiling Point: 273℃
• Flash Point: 119℃
• Appearance: /
• Density: 1.124
• Storage Temp.: 2-8°C
• CAS DataBase Reference: methyl 1-(2-ethoxy-2-oxoethyl)pyrrolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-(2-ethoxy-2-oxoethyl)pyrrolidine-3-carboxylate(142483-57-6)
• EPA Substance Registry System: methyl 1-(2-ethoxy-2-oxoethyl)pyrrolidine-3-carboxylate(142483-57-6)

Safety Data

• Hazardous Substances Data: 142483-57-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 1-(2-ethoxy-2-oxoethyl)pyrrolidine-3-carboxylate is used as a key intermediate in the synthesis of various drugs, contributing to the development of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, methyl 1-(2-ethoxy-2-oxoethyl)pyrrolidine-3-carboxylate serves as a building block for the preparation of other complex molecules, facilitating the creation of novel compounds with potential applications in various industries.
Used in Chemical Research:
Methyl 1-(2-ethoxy-2-oxoethyl)pyrrolidine-3-carboxylate is utilized as a versatile compound in chemical research, enabling the exploration of new reactions and the development of innovative synthetic pathways.

Upstream product

• 17012-21-4 1-benzylpyrrolidine-3-carboxylic acid methyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 21473-16-5 endo-3-hydroxy-1-azabicyclo<2.2.1>heptane 
• 21472-89-9 1-azabicyclo[2.2.1]heptan-3-one 

Relevant articles and documents

Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands

The effect of variation of the 1-azabicyclic substituent on the novel 1,2,3-triazol-4-yl-, 1,2,4-triazol-1-yl-, tetrazol-5-yl-, and tetrazol-2-yl- based muscarinic receptor ligands has been studied, and the exo- azabicyclic[2.2.1]hept-3-yl substituent was found to give the most potent and efficacious compounds. In addition, variation of the second substituent on 1,2,4-triazol-1-yl- and tetrazol-2-yl-based muscarinic receptor ligands has yielded a series of novel compounds with high potencies and efficacies, ranging from full agonists to antagonists. Small lipophilic electron withdrawing substituents give potent but low efficacy compounds, while small polar electron donating substituents give potent and efficacious compounds. The activity of these compounds is described in terms of a model of the receptor involving lipophilic and hydrogen bonding interactions. These compounds provide muscarinic ligands with high potency and a range of efficacies suitable for testing as candidate drugs in the treatment of Alzheimer's disease.