1425038-20-5

Basic information

• Product Name: methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate
• Synonyms: methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate;(2S,4R)-methyl 4-(3-chloro-7-methoxyquinoxalin-2-yloxy)pyrrolidine-2-carboxylate methanesulfonic acid;(4R)-4-[(3-Chloro-7-methoxy-2-quinoxalinyl)oxy]-L-proline methyl ester methanesulfonate;(2S,4R)-4-(3-chloro-7-methoxyquinoxalin-2-yloxy)-2-(methoxycarbonyl)pyrrolidiniurn methanesulfonate
• CAS NO: 1425038-20-5
• Molecular Formula: CH₄O₃S*C₁₅H₁₆ClN₃O₄
• Molecular Weight: 447.89048
• EINECS: -0
• Mol File: 1425038-20-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate(1425038-20-5)
• EPA Substance Registry System: methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate(1425038-20-5)

Safety Data

• Hazardous Substances Data: 1425038-20-5(Hazardous Substances Data)

Usage

Uses

1. Used in Antiviral Applications:
Methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate is used as an antiviral agent for its potential to inhibit viral replication and protect against various viral infections. Its antiviral properties make it a valuable compound in the development of new treatments for viral diseases.
2. Used as an Intermediate in Pharmaceutical Synthesis:
Methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate is used as an intermediate in the synthesis of Grazoprevir (M424985), a second-generation NS3/4A protease inhibitor. Grazoprevir is a significant compound in the treatment of hepatitis C virus (HCV) infections, and its development relies on the availability of this intermediate.
3. Used in COVID-19 Research:
As a COVID-19-related research product, methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate is used in the ongoing efforts to understand, treat, and develop vaccines for the novel coronavirus. Its antiviral properties and potential applications in drug development make it a valuable tool in the fight against COVID-19.

Upstream product

• 75-75-2 methanesulfonic acid 
• 39267-04-4 2,3-dichloro-6-methoxyquinoxaline 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 

Downstream Products

• 1425038-23-8 methyl (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-18,19-didehydro-1,1a,3,4,5,6,9,10,20,21,22,22a-dodecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3, 6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylate 
• 1206524-85-7 (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradeca-hydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid hydrate 
• 1350514-68-9 grazoprevir 
• 1206524-84-6 methyl (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxa-diazacyclononadecino[11,12-b]quinoxaline-8-carboxylate 
• 1206524-81-3 (2S,4R)-methyl 4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-1-((S)-3,3-dimethyl-2-((((1R,2R)-2-(pent-4-en-1-yl)cyclopropoxy)carbonyl)amino)butanoyl)pyrrolidine-2-carboxylate 

Relevant articles and documents

HCV NS3/4A protease inhibitor intermediate as well as synthesis method and application thereof

The invention belongs to the technical field of medicine, and particularly relates to an HCV NS3/4A protease inhibitor intermediate and a synthesis method and application thereof, wherein the synthesis method comprises the steps: taking 2,3-dichloro-6-methoxyquinoxaline and hydroxyproline methyl ester hydrochloride as initial raw materials, and carrying out a reaction; and extracting, drying and filtering to obtain (4R)-4-[(3-chloro-7-methoxy-2-quinoxalinyl)oxy]-L-proline methyl ester methanesulfonic acid. According to the invention, 2,3-dichloro-6-methoxyquinoxaline and hydroxyproline methylester hydrochloride are used as the initial raw materials, (4R)-4-[(3-chloro-7-methoxy-2-quinoxalinyl)oxy]-L-proline methyl ester methanesulfonic acid is synthesized finally by combining with subsequently added reactants, and the purity and yield of the product can be effectively improved by reasonably setting the component content ratio of all the raw materials; the purity of the final product isup to 99%, the yield can reach 90% or above, and industrial production is facilitated.