methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate

Base Information

Chemical Name:methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate
CAS No.:1425038-20-5
Molecular Formula:CH₄O₃S*C₁₅H₁₆ClN₃O₄
Molecular Weight:433.87
Hs Code.:
Mol file:1425038-20-5.mol

Synonyms:(2S,4R)-4-[(3-chloro-7-methoxyquinoxalin-2-yl)oxy]-2-(methoxycarbonyl)pyrrolidin-1-ium methanesulfonate

Suppliers and Price of methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,4R)-4-((3-Chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidiniumMethanesulfonate
250mg
$ 960.00

TRC
(2S,4R)-4-((3-Chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidiniumMethanesulfonate
100mg
$ 450.00

Total 25 raw suppliers

Chemical Property of methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate

Chemical Property:

Purity/Quality:

98% Min ^*data from raw suppliers

(2S,4R)-4-((3-Chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidiniumMethanesulfonate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (2S,4R)-4-((3-Chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium Methanesulfonate is an antiviral agent and Grazoprevir (M424985) intermediate. Grazoprevir is a second-generation NS3/4A protease inhibitor. It is a COVID19-related research product.

Technology Process of methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate

There total 1 articles about methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

: 75-75-2,98527-29-8
methanesulfonic acid

: 39267-04-4
2,3-dichloro-6-methoxyquinoxaline

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1425038-20-5
(2S,4R)-4-[(3-chloro-7-methoxyquinoxalin-2-yl)oxy]-2-(methoxycarbonyl)pyrrolidin-1-ium methanesulfonate

Guidance literature:: 2,3-dichloro-6-methoxyquinoxaline; L-4-hydroxyproline methyl ester hydrochloride; With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 23 - 30 ℃; for 15h;

methanesulfonic acid; at 20 - 30 ℃; for 10h; Temperature;

Reference yield:

: 1425038-20-5
(2S,4R)-4-[(3-chloro-7-methoxyquinoxalin-2-yl)oxy]-2-(methoxycarbonyl)pyrrolidin-1-ium methanesulfonate

: 1206524-85-7
(1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradeca-hydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid hydrate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / methanol / 35 °C / Inert atmosphere

2: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol / 5 h / 20 °C / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 12 h / 0 °C / Inert atmosphere

4: sodium hydroxide / methanol / 50 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 10 wt% Pd(OH)2 on carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; N,N-dimethyl acetamide;