142713-67-5Relevant articles and documents
A simple enantioconvergent and chemoenzymatic synthesis of optically active α-substituted amides
Szymanski, Wiktor,Westerbeek, Alja,Janssen, Dick B.,Feringa, Ben L.
supporting information; experimental part, p. 10712 - 10715 (2011/12/05)
Simple and efficient: The combination of an enzymatic, enantioinverting reaction with simple follow-up processes allows the transformation of readily available racemic compounds into versatile chiral α-substituted amides (see picture; Ms=methanesulfonyl).
CONTROL OF ENANTIOSELECTIVITY IN THE FORMATION OF A MODEL ALANINAMIDE FROM A 2-BROMOPROPANAMIDE
D'Angeli, Ferruccio,Marchetti, Paolo,Cavicchioni, Giorgio,Catelani, Giorgio,Nejad, F. Moftakhari Kamrani
, p. 155 - 158 (2007/10/02)
Reactions of (R)- or (S)-2-chloro or -bromopropanamides 1,2 and related compounds with benzylamine in the presence of AlCl3, Ag2O, or a lipase (CCL) in an organic solvent, are described.N,N'-Dibenzylalaninamide 6 of either optical activity is obtained from optically active 2 by proper use of Ag2O.