1427160-29-9

Upstream product

• 10227-63-1 1-(1H-benzo[d]imidazol-2-yl)-2-bromoethanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 7187-47-5 4-(1H-benzo[d]imidazol-2-yl)-1,3-thiazol-2-amine 
• 939-70-8 2-acetylbenzimidazole 

Relevant academic research and scientific papers

Synthesis of some new benzimidazole-thiazole derivatives as anticancer agents

4-(1H-benzo[d]imidazol-2-yl)thiazol-2-amine and its 1-methyl derivative (1) were reacted with different reagents such as acid anhydrides, malononitrile, chloroacetyl chloride, and aromatic aldehydes to produce the corresponding benzimidazole products 2-9, respectively. Also, 2-chloro-N-(4-(1-methyl-1H-benzo[d] imidazol-2-yl)thiazol-2-yl) acetamide (6) was reacted with diaminoethane, ortho-substituted aniline, thioglycolic acid, thiosemicarbazide derivatives, secondary amines, and potassium isothiocyanate to afford the corresponding derivatives 10-17, respectively. The cytotoxic activity of some newly synthesized derivativeswas studied against two different cell lines HepG2 and PC12. Compounds 9 and 15b showed promising anticancer activity against both types of the tested cancerous cell lines.

Synthesis and biological evaluation of some novel [4-(1H-Benzoimidazol-2- yl)-thiazol-2-yl]-benzylidene-amines and N-[4-(1H-Benzoimidazol-2-yl)-thiazol-2- yl]-N'-benzylidene-hydrazines

A new family of thiazole heterocycles, namely [4-(1H-benzoimidazol-2-yl)- thiazol-2-yl]-benzylidene-amines has been synthesized by the condensation of 4-(1H-Benzoimidazol-2-yl)-thiazol-2-ylamine with various aromatic aldehydes and N-[4-(1H-benzoimidazol-2-yl)-thiazol-2-yl]-N'-benzylidene-hydrazines through the cyclization of 1-(1H-benzoimidazol-2-yl)-2-bromo-ethanone with arylthiosemicarbazones. The target compounds are achieved by using 1-(1H-Benzoimidazol-2-yl)-ethanone as starting material. The chemical structures of all newly synthesized compounds were confirmed by their IR, 1H NMR and Mass spectral data. Further the compounds were used to evaluate their antimicrobial activity and found that the appreciable antimicrobial activity by some of the title compounds.