143239-03-6

Basic information

• Product Name: (2R)-3-[3-(benzyloxy)phenyl]-2-methylpropyl acetate
• CAS NO: 143239-03-6
• Molecular Formula: C₁₉H₂₂O₃
• Molecular Weight: 298.3762
• Mol File: 143239-03-6.mol

Chemical Properties

• Boiling Point: 425.4°C at 760 mmHg
• Flash Point: 181.2°C
• Density: 1.077g/cm³
• Vapor Pressure: 1.91E-07mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: (2R)-3-[3-(benzyloxy)phenyl]-2-methylpropyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-3-[3-(benzyloxy)phenyl]-2-methylpropyl acetate(143239-03-6)
• EPA Substance Registry System: (2R)-3-[3-(benzyloxy)phenyl]-2-methylpropyl acetate(143239-03-6)

Safety Data

• Hazardous Substances Data: 143239-03-6(Hazardous Substances Data)

Upstream product

• 141-78-6 ethyl acetate 
• 143291-83-2 3-(3-Benzyloxy-phenyl)-2-methyl-propan-1-ol 
• 108-05-4 vinyl acetate 

Relevant articles and documents

Kinetic resolution of primary 2-methyl-substituted alcohols via Pseudomonas cepacia lipase-catalysed enantioselective acylation

The enantioselectivities of lipases from Pseudomonas cepacia (PFL, Amano PS, etc.) towards a series of primary 2-methyl-substituted alcohols using vinyl acetate as the acyl donor in transesterifications in organic solvents were studied. In terms of enantioselectivity, the best results were found for 3-aryl-2-methylpropan-1-ols with enantiomeric ratios (E-values) over 100 in most cases, whereas other 3-substituted primary 2-methylpropan-1-ols generally displayed lower enantioselectivities: 3-cycloalkyl-2-methylpropan-1-ols (E ≈ 20) and 2-methylalkan-1-ols (E ≈ 10). Moving the aryl group closer or further away from the chiral centre resulted in low enantioselectivities: 2-arylpropan-1-ols (E 10), 2-methyl-4-(2-thienyl)butan-1-ol (E = 12), 2-methyl-5-(2-thienyl)pentan-1-ol (E = 3.2) and 2-methyl-6-(2-thienyl)hexan-1-ol (E = 3.8).

Enzymatic preparation of optically active fungicide intermediates in aqueous and in organic media

Pure stereoisomers of two new triazole and morpholine fungicides have been prepared starting from enzymatically synthesized chiral alcohol intermediates.Two resolution strategies compared are: lipase-catalyzed hydrolysis of corresponding acetates in water and lipase-catalyzed transesterification of alcohols in organic solvents.The antifungal activity of optically pure enantiomers of the synthesized fungicides investigated in vitro and in vivo against a variety of fungi, show an activity ratio (R-form/S-form) up to 400.