cas 14328-49-5, L-2-Amino-3-ethylpentanoic acid | Articles data ｜lookchem

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14328-49-5

Articles about 14328-49-5Total 3 be found

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Substrate-product analogue inhibitors of isoleucine 2-epimerase from: Lactobacillus buchneri by rational design
A rational approach that may be applied to a broad class of enzyme-catalyzed reactions to design enzyme inhibitors affords a powerful strategy, facilitating the development of drugs and/or molecular probes of enzyme mechanisms. A strategy for the developm
Sorbara, Noa T.,MacMillan, Joshua W. M.,McCluskey, Gregory D.,Bearne, Stephen L.
p. 8618 - 8627
(2019)
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Discovery of begacestat, a Notch-1-sparing γ-secretase inhibitor for the treatment of Alzheimer's disease
SAR on HTS hits 1 and 2 led to the potent, Notch-1-sparing GSI 9, which lowered brain Aβ in Tg2576 mice at 100 mg/kg po. Converting the metabolically labile methyl groups in 9 to trifluoromethyl groups afforded the more stable analogue 10, which had impro
Mayer, Scott C.,Kreft, Anthony F.,Harrison, Boyd,Abou-Gharbia, Magid,Antane, Madelene,Aschmies, Suzan,Atchison, Kevin,Chlenov, Michael,Cole, Derek C.,Comery, Thomas,Diamantidis, George,Ellingboe, John,Fan, Kristi,Galante, Rocco,Gonzales, Cathleen,Ho, Douglas M.,Hoke, Molly E.,Hu, Yun,Huryn, Donna,Jain, Uday,Jin, Mei,Kremer, Kenneth,Kubrak, Dennis,Lin, Melissa,Lu, Peimin,Magolda, Ron,Martone, Robert,Moore, William,Oganesian, Aram,Pangalos, Menelas N.,Porte, Alex,Reinhart, Peter,Resnick, Lynn,Riddell, David R.,Sonnenberg-Reines, June,Stock, Joseph R.,Sun, Shaiu-Ching,Wagner, Erik,Wang, Ting,Woller, Kevin,Xu, Zheng,Zaleska, Margaret M.,Zeldis, Joseph,Zhang, Minsheng,Zhou, Hua,Jacobsen, J. Steven
p. 7348 - 7351
(2008)
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Synthesis of L α amino acids structurally related to isoleucine
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Praetorius,Flossdorf,Kula
p. 3079 - 3090
(2007/10/05)

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14328-77-9
(S)-2-(benzyloxycarbonylamino)-3-ethylpentanoic acid

Chemical Properties

Melting Point: >300°C
Solubility:Aqueous Acid (Slightly), Methanol (Slightly, Heated), Water (Slightly)
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
PSA: 63.32000
LogP: 1.53480

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