- Substrate-product analogue inhibitors of isoleucine 2-epimerase from: Lactobacillus buchneri by rational design
-
A rational approach that may be applied to a broad class of enzyme-catalyzed reactions to design enzyme inhibitors affords a powerful strategy, facilitating the development of drugs and/or molecular probes of enzyme mechanisms. A strategy for the developm
- Sorbara, Noa T.,MacMillan, Joshua W. M.,McCluskey, Gregory D.,Bearne, Stephen L.
-
p. 8618 - 8627
(2019/10/02)
-
- A practical synthesis of 3-ethyl-l-norvaline
-
An efficient process for the synthesis of 3-ethyl-l-norvaline has been developed. The route makes use of a Strecker reaction, whereby (S)-(-)-α-methylbenzylamine acts as a chiral auxiliary to provide nearly diastereomerically pure α-amino nitrile. Crystal
- Resnick, Lynn,Galante, Rocco J.
-
p. 846 - 849
(2007/10/03)
-
- Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
-
Methods for production of chirally pure α-amino acids and N-sulfonyl α-amino acids are described. An aldehyde and a cyanide salt are reacted with an α-methylbenzylamine to afford product. The product reacts with a strong acid, neutralized, and extracted.
- -
-
Page column 22
(2008/06/13)
-
- Production of chirally pure alpha-amino acids and N-sulfonyl alpha-amino acids
-
Methods for production of chirally pure α-amino acids and N-sulfonyl α-amino acids are described. An aldehyde and a cyanide salt are reacted with an α-methylbenzylamine to afford product. The product reacts with a strong acid, neutralized, and extracted.
- -
-
-
- Heterocyclic sulfonamide inhibitors of beta amyloid production
-
Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs there
- -
-
-