143445-03-8

Basic information

• Product Name: 2-({3-methoxy-2-propoxy-5-[(2R,5R)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl]phenyl}sulfonyl)ethanol
• CAS NO: 143445-03-8
• Molecular Formula: C₂₅H₃₄O₉S
• Molecular Weight: 510.5971
• Mol File: 143445-03-8.mol

Chemical Properties

• Boiling Point: 684°C at 760 mmHg
• Flash Point: 367.5°C
• Density: 1.224g/cm³
• Vapor Pressure: 1.2E-19mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 2-({3-methoxy-2-propoxy-5-[(2R,5R)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl]phenyl}sulfonyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-({3-methoxy-2-propoxy-5-[(2R,5R)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl]phenyl}sulfonyl)ethanol(143445-03-8)
• EPA Substance Registry System: 2-({3-methoxy-2-propoxy-5-[(2R,5R)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl]phenyl}sulfonyl)ethanol(143445-03-8)

Safety Data

• Hazardous Substances Data: 143445-03-8(Hazardous Substances Data)

Upstream product

• 140705-18-6 (S)-5-[3-(2-Hydroxy-ethylsulfanyl)-5-methoxy-4-propoxy-phenyl]-dihydro-furan-2-one 
• 497-19-8 sodium carbonate 
• 141869-80-9 (S)-5-{3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethanesulfonyl]-5-methoxy-4-propoxy-phenyl}-dihydro-furan-2-one 
• 140705-19-7 (S)-5-[3-(2-Hydroxy-ethanesulfonyl)-5-methoxy-4-propoxy-phenyl]-dihydro-furan-2-one 
• 133095-92-8 4-(3-Iodo-5-methoxy-4-propoxy-phenyl)-4-oxo-butyric acid tert-butyl ester 
• 133095-94-0 (S)-4-Hydroxy-4-(3-iodo-5-methoxy-4-propoxy-phenyl)-butyric acid 
• 133095-95-1 4[3-Methoxy-4-n-propyloxy-5-iodophenyl]-4S-butyrolactone 
• 481725-17-1 (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-en-3-ol 
• 481725-18-2 (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-ene 
• 481725-20-6 (2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]tetrahydrofuran 
• 481725-19-3 (2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran 
• 481725-15-9 (S)-((1S,2S,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl)-(3,4,5-trimethoxy-phenyl)-methanol 
• 481725-11-5 1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene 
• 481725-16-0 (1R,2S,5S,6R,7S)-5-[(3',4',5')-trimethoxyphenyl]-4,10-dioxatricyclo[5.2.1.0^2,6]dec-8-en-3-one 

Relevant articles and documents

Enantioselective synthesis of the PAF antagonist MK-287

Following a general method of synthesis of optically active 2,5-disubstituted tetrahydrofurans, an enantioselective synthesis of the PAF antagonist, MK-287 is described.

CERTAIN 2,5-DIARYL TETRAHYDROFURANS AND ANALOGS THEREOF AS PAF ANTAGONISTS

The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) STR1 wherein R 4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group, Y is an alkyl or substituted alkyl group and R 6 is an alkoxy or a substituted alkoxy or alkyl group.