2-({3-methoxy-2-propoxy-5-[(2R,5R)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl]phenyl}sulfonyl)ethanol

Base Information

Chemical Name:2-({3-methoxy-2-propoxy-5-[(2R,5R)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl]phenyl}sulfonyl)ethanol
CAS No.:143445-03-8
Molecular Formula:C₂₅H₃₄O₉S
Molecular Weight:510.606
Hs Code.:

Synonyms:Ethanol,2-[[3-methoxy-2-propoxy-5-[tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]sulfonyl]-,trans-(?à)-; Ethanol,2-[[3-methoxy-2-propoxy-5-[tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]sulfonyl]-,trans-; L 668750

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Chemical Property of 2-({3-methoxy-2-propoxy-5-[(2R,5R)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl]phenyl}sulfonyl)ethanol

Chemical Property:

Vapor Pressure:1.2E-19mmHg at 25°C
Boiling Point:684°Cat760mmHg
Flash Point:367.5°C
Density:1.224g/cm³

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-({3-methoxy-2-propoxy-5-[(2R,5R)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl]phenyl}sulfonyl)ethanol

There total 27 articles about 2-({3-methoxy-2-propoxy-5-[(2R,5R)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl]phenyl}sulfonyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 140705-14-2
(2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfonyl)-4-propoxyphenyl]tetrahydrofuran

: 135947-75-0,143445-03-8
MK 287

Guidance literature:: With oxalic acid; In methanol; at 23 ℃; for 20h;
DOI:10.1021/jo00052a013

Reference yield:

: 1-(5-(2-hydroxyethylsulfonyl)-4-n-propoxy-3-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-butan-1,4-diol

: 497-19-8
sodium carbonate

: 143445-03-8
trans 2-(5-(2-hydroxyethylsulfonyl)-4-n-propoxy-3-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran

Guidance literature:: With trifluoroacetic acid; In chloroform;

Reference yield:

: 133095-95-1
4[3-Methoxy-4-n-propyloxy-5-iodophenyl]-4S-butyrolactone

: 135947-75-0,143445-03-8
MK 287

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / copper bronze / dimethylformamide / 22 h / 108 °C

2: 95 percent / magnesium monoperoxyphthalate / H₂O; acetonitrile / 2 h / 50 °C

3: 95 percent / imidazole / dimethylformamide / 2 h / 25 °C

4: 97 percent / diisobutylaluminum hydride / toluene / 1 h / -70 °C

5: 1) Mg

6: 94 percent / oxalic acid / methanol / 20 h / 23 °C

With 1H-imidazole; oxalic acid; copper; diisobutylaluminium hydride; magnesium monoperoxyphthalate hexahydrate; magnesium; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo00052a013