143536-52-1

Basic information

• Product Name: ethyl 5-(3-hydroxyphenyl)pentanoate
• Synonyms: ethyl 5-(3-hydroxyphenyl)pentanoate;Benzenepentanoic acid, 3-hydroxy-, ethyl ester
• CAS NO: 143536-52-1
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.282
• Mol File: 143536-52-1.mol

Chemical Properties

• Boiling Point: 346.4 °C at 760 mmHg
• Flash Point: 142.5 °C
• Appearance: /
• Density: 1.075
• Vapor Pressure: 2.89E-05mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: ethyl 5-(3-hydroxyphenyl)pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-(3-hydroxyphenyl)pentanoate(143536-52-1)
• EPA Substance Registry System: ethyl 5-(3-hydroxyphenyl)pentanoate(143536-52-1)

Safety Data

• Hazardous Substances Data: 143536-52-1(Hazardous Substances Data)

Usage

Uses

Used in Flavor and Fragrance Industry:
Ethyl 5-(3-hydroxyphenyl)pentanoate is used as a flavoring agent in food and beverages for its pleasant and distinctive aroma, enhancing the taste and sensory experience of various products.
Used in Perfume Production:
Ethyl 5-(3-hydroxyphenyl)pentanoate is used as a fragrance ingredient in perfumes, contributing to the creation of unique and appealing scents due to its sweet and slightly spicy notes.
Used in Cosmetics:
Ethyl 5-(3-hydroxyphenyl)pentanoate is used in the production of cosmetics for its pleasant scent, adding a desirable aroma to skincare and beauty products, thereby enhancing consumer appeal and experience.

InChI:InChI=1/C13H18O3/c1-2-16-13(15)9-4-3-6-11-7-5-8-12(14)10-11/h5,7-8,10,14H,2-4,6,9H2,1H3

Upstream product

• 1400705-30-7 5-(3-hydroxy-phenyl)-4-pentenoic acid ethyl ester 
• 1968-40-7 ethyl 4-pentenoate 
• 626-02-8 3-Iodophenol 
• 100-83-4 meta-hydroxybenzaldehyde 
• 13709-05-2 3-methoxymethoxybenzaldehyde 
• 1314760-23-0 C₁₁H₁₄O₃ 
• 1314760-24-1 C₁₅H₂₀O₄ 
• 14755-02-3 3-hydroxycinnamic acid 
• 3943-96-2 3-(3-hydroxyphenyl)acrylic acid ethyl ester 
• 96251-92-2 (E)-3-(3-hydroxyphenyl)acrylic acid ethyl ester 
• 75677-04-2 3-<3-(benzyloxy)phenyl>propanal 
• 75849-10-4 ethyl 3-<3-(benzyloxy)phenyl>propanoate 
• 34708-60-6 3-(3-hydroxy-phenyl)propionic acid ethyl ester 
• 14755-02-3 3-hydroxy-trans-cinnamic acid 

Downstream Products

• 1400703-82-3 (S)-2-({2-[4-(3-hydroxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 
• 1400706-23-1 C₂₆H₃₀N₄O₅S 
• 1400706-22-0 C₂₉H₃₄N₄O₅S 
• 1400706-21-9 C₂₉H₄₀N₄O₆ 
• 1400705-51-2 2-[4-(3-allyloxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carboxylic acid methyl ester 
• 1400706-25-3 C₁₄H₂₀N₂O 
• 1400706-24-2 C₁₆H₂₂O₂S 

Relevant articles and documents

PYRIMIDINE AMIDE COMPOUNDS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.

Discovery of S1P agonists with a dihydronaphthalene scaffold

Structure-activity relationship of sphingosine-1-phosphate receptor agonists was examined. Cinnamyl derivative 1 was modified to improve S1P 1 agonistic activity as well as selectivity over S1P3 agonistic activity. Dihydronaphthalene derivative 10d was identified as a potent S1P1 receptor agonist with high selectivity against S1P3 and enhanced efficacy in lowering peripheral lymphocyte counts in mice.

COMPOUND CAPABLE OF BINDING S1P RECEPTOR AND PHARMACEUTICAL USE THEREOF

A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like. wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.

Regioselective synthesis of 1,8-dihydroxytetralins through a tandem reduction/intramolecular hydroxyalkylation of 4-(3-hydroxyphenyl)alkanoates

A series of 4-(3-hydroxyphenyl)butanoates 3 has been prepared and transformed into 1,8-dihydroxytetralins of general formula 2 by treatment with 2 equivalents of DIBALH followed by quenching with aqueous NH4Cl. A possible mechanism for this novel totally regioselective intramolecular hydroxyalkylation is suggested and the factors affecting the stability of 1,8-dihydroxytetralins 2 are also discussed.

Tandem Reduction / Intramolecular Hydroxyalkylation of (3-Hydroxyphenyl)alkanoates: a New Regioselective Approach to 1,8-Dihydroxytetralins

4-(3-hydroxyphenyl)-butanoates 4, on treatment with DIBALH, followed by hydrolytic work-up, undergo a novel completely regioselective intramolecular hydroxyalkylation reaction to give 1,8-dihydroxytetralins.The yield of the reaction depends heavily on the structure of starting material, best results being achieved with 3,3-disubstituted butanoates.