75677-04-2

Basic information

• Product Name: Benzenepropanal, 3-(phenylMethoxy)-
• Synonyms: Benzenepropanal, 3-(phenylMethoxy)-;3-(3-phenylmethoxyphenyl)propanal
• CAS NO: 75677-04-2
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.29704
• Mol File: 75677-04-2.mol

Chemical Properties

• Boiling Point: 373.8°C at 760 mmHg
• Flash Point: 163.1°C
• Appearance: /
• Density: 1.088g/cm³
• Vapor Pressure: 8.71E-06mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: Benzenepropanal, 3-(phenylMethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanal, 3-(phenylMethoxy)-(75677-04-2)
• EPA Substance Registry System: Benzenepropanal, 3-(phenylMethoxy)-(75677-04-2)

Safety Data

• Hazardous Substances Data: 75677-04-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H16O2/c17-11-5-9-14-8-4-10-16(12-14)18-13-15-6-2-1-3-7-15/h1-4,6-8,10-12H,5,9,13H2

Upstream product

• 14755-02-3 3-hydroxycinnamic acid 
• 100-44-7 benzyl chloride 
• 1424-74-4 3-(3-hydroxyphenyl)propanol 
• 96251-92-2 (E)-3-(3-hydroxyphenyl)acrylic acid ethyl ester 
• 34708-60-6 3-(3-hydroxy-phenyl)propionic acid ethyl ester 
• 14755-02-3 3-hydroxy-trans-cinnamic acid 
• 1700-37-4 3-Benzyloxybenzaldehyde 
• 495399-41-2 methyl 3-(3-benzyloxyphenyl)propenoate 
• 476458-89-6 3-(3-benzyloxy-phenyl)-propionic acid methyl ester 
• 57668-35-6 3-[3-(Benzyloxy)phenyl]-1-propanol 
• 3943-96-2 3-(3-hydroxyphenyl)acrylic acid ethyl ester 

Downstream Products

• 143536-52-1 ethyl 5-(3-hydroxyphenyl)pentanoate 
• 167935-97-9 methyl (S)-2-amino-3-(3-hydroxyphenyl)propanoate 
• 222556-14-1 (S)-1-[(S)-3-(3-Benzyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propionyl]-hexahydro-pyridazine-3-carboxylic acid methyl ester 
• 222556-20-9 (S)-3-(3-(benzyloxy)phenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid 
• 447461-03-2 (S)-N^α-tert-butoxycarbonyl-(m-benzyloxy)phenylalanine methyl ester 
• 900800-02-4 2S-tert-butoxycarbonylamino-3-(3-hydroxyphenyl)propionic acid methyl ester 
• 1260603-52-8 C₂₂H₂₄O₅ 
• 129649-70-3 ethyl 5-<3-(benzyloxy)phenyl>-3-methylpent-2-enoate 
• 129649-57-6 4-<3-(benzyloxy)phenyl>butan-2-one 
• 75677-50-8 5H-r,7-(m-benzyloxyphenyl)-cis-3-hydroxy-trans-3-methylheptan-5-olide 
• 127223-35-2 2,3-dihydro-7-benzyloxy-1H-indene-1-spiro-2'-(2H-indene)-1',3'-dione 

Relevant articles and documents

Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase inhibitors: 2-oxetanones with a side chain mimicking the folded structure of 1233A.

To mimic the folded side chain conformation of 1233A (1), which is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase inhibitor, 1233A analogs with aromatic rings in the side chain were synthesized. The 2-oxetanone moiety was kept intact. Among 1233A and its synthetic analogs, trans-3-hydroxymethyl-4-[2-(7-methoxycarbonyl-1-naphthyl)ethyl]-2-oxe tanone (23) showed the highest HMG-CoA synthase inhibitory activity in vitro. The structure-activity relationship at the side chain is discussed.

Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 2-Oxetanones with a meta-substituent on the benzene ring in the side chain

Isosteric side chain analogs of 3a were synthesized and tested for inhibitory activities towards 3-hydroxy-3-methylglutaryl coenzyme A (HMG- CoA) synthase and upon cholesterol production in Hep G2 cells and in mouse liver. It became clear that the lipophi

Regioselective synthesis of 1,8-dihydroxytetralins through a tandem reduction/intramolecular hydroxyalkylation of 4-(3-hydroxyphenyl)alkanoates

A series of 4-(3-hydroxyphenyl)butanoates 3 has been prepared and transformed into 1,8-dihydroxytetralins of general formula 2 by treatment with 2 equivalents of DIBALH followed by quenching with aqueous NH4Cl. A possible mechanism for this novel totally regioselective intramolecular hydroxyalkylation is suggested and the factors affecting the stability of 1,8-dihydroxytetralins 2 are also discussed.

Intramolecular arylation of a soft carbon centre using Mn(III) acetate: Studies towards the spirostructure of fredericamycin-A

The potential of Mn(III) acetate has been explored for oxidative cyclisation in the indanediones 3, for the synthesis of the core subunit 2 of fredericamycin-A(1).

Tandem Reduction / Intramolecular Hydroxyalkylation of (3-Hydroxyphenyl)alkanoates: a New Regioselective Approach to 1,8-Dihydroxytetralins

4-(3-hydroxyphenyl)-butanoates 4, on treatment with DIBALH, followed by hydrolytic work-up, undergo a novel completely regioselective intramolecular hydroxyalkylation reaction to give 1,8-dihydroxytetralins.The yield of the reaction depends heavily on the structure of starting material, best results being achieved with 3,3-disubstituted butanoates.