143759-63-1

Basic information

• Product Name: 1-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}-3-(phenylamino)propan-2-ol
• Synonyms: 1-(4,4-bis(4-fluorophenyl)butyl)-4-(2-hydroxy-3-(phenylamino)propyl)piperazine
• CAS NO: 143759-63-1
• Molecular Formula: C₂₉H₃₅F₂N₃O
• Molecular Weight: 479.6045
• Mol File: 143759-63-1.mol

Chemical Properties

• Boiling Point: 627°C at 760 mmHg
• Flash Point: 333°C
• Density: 1.175g/cm³
• Vapor Pressure: 1.38E-16mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 1-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}-3-(phenylamino)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}-3-(phenylamino)propan-2-ol(143759-63-1)
• EPA Substance Registry System: 1-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}-3-(phenylamino)propan-2-ol(143759-63-1)

Safety Data

• Hazardous Substances Data: 143759-63-1(Hazardous Substances Data)

Upstream product

• 490576-34-6 1-[4,4-bis(4-fluorophenyl)butyl]-4-[3-(N-tert-butoxycarbonyl-N-phenylamino)-2-hydroxypropyl]piperazine 
• 143760-30-9 1-[4,4-bis(4-fluorophenyl)butyl]-4-[3-[(N-ethoxycarbonyl-N-phenyl)amino]-2-hydroxypropyl]piperazine 
• 101-99-5 N-carboethoxyaniline 
• 5631-35-6 1-[4,4-bis(4-fluorophenyl)butyl]piperazine 
• 42592-04-1 N-(2,3-epoxypropyl)-N-ethoxycarbonylaniline 
• 3422-01-3 tert-butyl phenylcarbamate 
• 143759-57-3 1-[4,4-bis(4-fluorophenyl)butyl]-4-(2,3-epoxypropyl)piperazine 
• 490576-33-5 N-tert-butoxycarbonyl-N-(2,3-epoxypropyl)aniline 

Relevant articles and documents

Antioxidative activities of novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter

A new series of diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter (DAT), which were modified at both the diphenylalkyl moiety and the phenyl ring in the phenylamino moiety of 1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine 1, was evaluated for their inhibitory activities against auto-oxidative lipid peroxidation in canine brain homogenates. Some of these were approximately equivalent in activity to α-tocopherol as a potent antioxidant with IC50 values of low micromolar order, and the 4-hydroxyphenyl derivative 11 showed the most potent antioxidative activity with an IC 50 value of 0.32μM, exhibiting approximately 5-fold more potent activity than α-tocopherol. The structure-activity relationship (SAR) studies of the antioxidative activity of these derivatives are presented.

Syntheses of novel diphenyl piperazine derivatives and their activities as inhibitors of dopamine uptake in the central nervous system

A new series of diphenyl piperazine derivatives containing the phenyl substituted aminopropanol moiety, which were modified at sites between the diphenyl and piperazine moieties, was prepared and evaluated for dopamine transporter binding affinity with [

Novel diphenylalkyl piperazine derivatives with dual calcium antagonistic and antioxidative activities

Two types of novel diphenylalkyl piperazine derivatives containing the thio or aminopropanol moiety substituted by phenyl or benzyl group were synthesized, and evaluated for their calcium antagonistic and antioxidative activities. These compounds showed apparent inhibitions against KCl-induced contractions in isolated rat aorta. Among them, phenylamino compound 9 and benzylamino compound 13 also possessed potent inhibitory activities against auto-oxidative lipid peroxidations in canine brain homogenates. Two representative compounds 3a and 9 were evaluated for their inhibitory activities against KCl-induced contractions in isolated canine arteries (basilar, coronary, mesenteric, and renal). Both compounds showed the most potent inhibitions to basilar artery.

Diphenylpiperazine derivative and drug for circulatory organ containing the same

A diphenylpiperazine derivative represented by general formula (1), salt thereof, and drug for the circulatory organs containing the same as the active ingredient: STR1 wherein R1 and R2 may be the same or different from each other a