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DESMETHYL RIZATRIPTAN, also known as N10-Monodesmethyl Rizatriptan (Rizatriptan EP Impurity I), is a metabolite of Rizatriptan. It is derived from the parent compound Rizatriptan, which is a medication used to treat migraines. DESMETHYL RIZATRIPTAN is formed through the metabolic process in the body, specifically through the demethylation of Rizatriptan.

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  • 144034-84-4 Structure
  • Basic information

    1. Product Name: DESMETHYL RIZATRIPTAN
    2. Synonyms: DESMETHYL RIZATRIPTAN;N10-Monodesmethyl Rizatriptan;N-Methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine;N-MonodesMethyl Rizatriptan;Rizatriptan N-monodesmethyl
    3. CAS NO:144034-84-4
    4. Molecular Formula: C14H17N5
    5. Molecular Weight: 255.32
    6. EINECS: 604-604-1
    7. Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Heterocycles
    8. Mol File: 144034-84-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 515.644°C at 760 mmHg
    3. Flash Point: 265.652°C
    4. Appearance: /
    5. Density: 1.269g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.673
    8. Storage Temp.: Refrigerator
    9. Solubility: DMSO (Slightly), Methanol (Slightly)
    10. CAS DataBase Reference: DESMETHYL RIZATRIPTAN(CAS DataBase Reference)
    11. NIST Chemistry Reference: DESMETHYL RIZATRIPTAN(144034-84-4)
    12. EPA Substance Registry System: DESMETHYL RIZATRIPTAN(144034-84-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 144034-84-4(Hazardous Substances Data)

144034-84-4 Usage

Uses

Used in Pharmaceutical Industry:
DESMETHYL RIZATRIPTAN is used as an impurity reference substance for the quality control and analysis of Rizatriptan in the pharmaceutical industry. As a metabolite of Rizatriptan, it plays a role in understanding the pharmacokinetics and pharmacodynamics of the parent drug, which can be crucial for drug development and optimization.
Additionally, DESMETHYL RIZATRIPTAN may be used as a research compound to study the metabolic pathways and effects of Rizatriptan in the body. This can contribute to the development of new medications or improved formulations with better efficacy and safety profiles for the treatment of migraines and other related conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 144034-84-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,0,3 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 144034-84:
(8*1)+(7*4)+(6*4)+(5*0)+(4*3)+(3*4)+(2*8)+(1*4)=104
104 % 10 = 4
So 144034-84-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H17N5/c1-15-5-4-12-7-17-14-3-2-11(6-13(12)14)8-19-10-16-9-18-19/h2-3,6-7,9-10,15,17H,4-5,8H2,1H3

144034-84-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N10-Monodesmethyl Rizatriptan

1.2 Other means of identification

Product number -
Other names N-methyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:144034-84-4 SDS

144034-84-4Downstream Products

144034-84-4Relevant articles and documents

Synthesis and characterization of potential impurities of the antimigraine drug, rizatriptan benzoate

Sarma, P. Seetharama,Rao, C. Nageswar,Surayanarayana,Reddy, Padi Pratap,Khalilluah,Praveen, Cherukupally

, p. 603 - 612 (2008)

Rizatriptan benzoate is a recently developed antimigraine drug used for the treatment of migraines and severe headaches. In the synthesis of rizatriptan benzoate in bulk,various impurities are formed. The present work details the development of a simple a

N-Desmethyltriptans: One pot efficient synthesis of N-methyl-2-5- [substituted- 1H- indole-3-yl]ethanamines

Mittapelli, Vasantha,Ray, Puma Chandra,Chauhan, Yogendra Kumar,Datta, Debashish

experimental part, p. 590 - 594 (2010/01/06)

A straightforward and highly improved method to synthesize N-methyl-2-[5-[substituted-lH-indole-3-yl]ethanamines 4-6, which are the metabolites of tryptans 1-3, is reported. The significance of the process is its simplicity and efficiency in isolating the N- desmethyltriptans derivatives as a free base.

Azetidine, pyrrolidine and piperidine derivatives as 5-HT receptor agonists

-

, (2008/06/13)

PCT No. PCT/GB97/01137 Sec. 371 Date Oct. 14, 1998 Sec. 102(e) Date Oct. 14, 1998 PCT Filed Apr. 24, 1997 PCT Pub. No. WO97/42189 PCT Pub. Date Nov. 13, 1997A class of compounds of formula (I) wherein Z, E, Q, T, U, V, W, M, R1, R7 and R8 are as defined herein; are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5-HT1D alpha receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT1D alpha receptor subtype relative to the 5-HT1D beta subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists.

Triazole containing indole derivatives

-

, (2008/06/13)

A class of substituted imidazole, triazole and tetrazole derivatives are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.

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