114094-45-0

Usage

Uses

A precursor to gamma-methylaminobuteraldehyde.

Upstream product

• 220803-77-0 N-(4,4-diethoxybutyl)-formamide 
• 74-88-4 methyl iodide 
• 6139-83-9 4-chloro-1,1-diethoxybutane 
• 74-89-5 methylamine 
• 6346-09-4 4-aminobutyrylaldehyde diethylacetal 

Downstream Products

• 76103-58-7 2-(1-methylpyrrolidin-2-yl)-1-phenylethanon 
• 88919-51-1 N-methyl-2-[5-[[(methylamino)sulphonyl]methyl]-1H-indol-3-yl]ethanamine 
• 144034-84-4 N-methyl-5-(1H-1,2,4-triazol-1-yl-methyl)-1H-indol-3-ethanamine 
• 1189798-70-6 (2-(5-chloro-1-(3-phenylpropyl)-1H-indol-3-yl)ethyl)methylamine 
• 1189798-78-4 2-(1-(2-cyclohexylethyl)-5-methyl-1H-indol-3-yl)-N-methylethanamine 
• 1189798-82-0 2-(1-(4-fluorophenethyl)-5-chloro-1H-indol-3-yl)-N-methylethanamine 

Relevant academic research and scientific papers

BROAD-SPECTRUM CARBAPENEMS

The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.

N-Desmethyltriptans: One pot efficient synthesis of N-methyl-2-5- [substituted- 1H- indole-3-yl]ethanamines

A straightforward and highly improved method to synthesize N-methyl-2-[5-[substituted-lH-indole-3-yl]ethanamines 4-6, which are the metabolites of tryptans 1-3, is reported. The significance of the process is its simplicity and efficiency in isolating the N- desmethyltriptans derivatives as a free base.

Determination of methylputrescine oxidase by high performance liquid chromatography

N-Methyl-Δ1-pyrrolinium chloride, the product of the title enzyme, was synthesized by methylation of aminobutyraldehyde diethylacetal followed by acidic cleavage. After purification to homogeneity, it was characterized by NMR and UV spectroscopy. The compound had an absorption maximum at 210 nm; previous data indicating a maximum at 267 nm were shown to arise from an impurity. An HPLC method for the assay of N-methylputrescine oxidase from plant material was developed based on the separation of N-methyl-Δ1-pyrrolinium chloride on a cation exchange column and direct detection at 210 nm. The enzyme activity was measured in the protein fraction extracted from plant roots and treated by gel filtration on disposable PD 10 columns. A Km value of 1.9 mM was determined for methylputrescine and the enzyme from tobacco roots. The enzyme activities from N. tabacum and Datura stramonium were compared.