144163-92-8

Basic information

• Product Name: Isoquinolin-1-ylMethyl-Methyl-aMine
• Synonyms: Isoquinolin-1-ylMethyl-Methyl-aMine;1-(isoquinolin-1-yl)-N-methylmethanamine
• CAS NO: 144163-92-8
• Molecular Formula: C11H12N2
• Molecular Weight: 172.22638
• Mol File: 144163-92-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Isoquinolin-1-ylMethyl-Methyl-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinolin-1-ylMethyl-Methyl-aMine(144163-92-8)
• EPA Substance Registry System: Isoquinolin-1-ylMethyl-Methyl-aMine(144163-92-8)

Safety Data

• Hazardous Substances Data: 144163-92-8(Hazardous Substances Data)

Upstream product

• 119-65-3 isoquinoline 
• 4494-18-2 isoquinoline-1-carbaldehyde 
• 74-89-5 methylamine 

Relevant articles and documents

Base-Promoted Tandem Synthesis of 2-Azaaryl Tetrahydroquinolines

A novel method to synthesize 2-azaaryl tetrahydroquinolines by the base-promoted tandem reaction of azaaryl methyl amines and styrene derivatives is reported (over 30 examples, yields up to 95%). Mechanistic probe experiments demonstrate that the deprotonation of the benzylic C-H bond and the addition to the styrene vinyl group proceeds via the SNAr mechanism.

Introduction of Quinolines and Isoquinolines onto Nonactivated α-C-H Bond of Tertiary Amides through a Radical Pathway

Treatment of quinolines and isoquinolines with benzoyl peroxide in tertiary amides, such as N,N-dimethylacetamide, N,N-dimethylpropionamide, and N-acetylpyrrolidine, etc., under irradiation with a Hg lamp in the temperature range of 35 °C to 40 °C gave C-C-bonded quinolines and isoquinolines bearing amide groups with high regioselectivity in good to moderate yields, respectively, under transition-metal-free conditions.