4494-18-2

Basic information

• Product Name: ISOQUINOLINE-1-CARBALDEHYDE
• Synonyms: ISOQUINOLINE-1-CARBALDEHYDE;1-isquinolinecarboxaldehyde;1-FORMYLISOQUINOLINE;1-Isoquinolinecarboxaldehyde;Isoquinoline-1-carbaldehyde ,97%
• CAS NO: 4494-18-2
• Molecular Formula: C₁₀H₇NO
• Molecular Weight: 157.17
• EINECS: 200-258-5
• Product Categories: Isoquinoline Derivertives
• Mol File: 4494-18-2.mol
• Article Data: 26

Chemical Properties

• Melting Point: 55-55.5 °C
• Boiling Point: 308.561 °C at 760 mmHg
• Flash Point: 148.356 °C
• Appearance: /
• Density: 1.224 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.687
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 2.06±0.30(Predicted)
• CAS DataBase Reference: ISOQUINOLINE-1-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOQUINOLINE-1-CARBALDEHYDE(4494-18-2)
• EPA Substance Registry System: ISOQUINOLINE-1-CARBALDEHYDE(4494-18-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-20/21/22
• Safety Statements: 26-36/37-24/25
• Hazardous Substances Data: 4494-18-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C10H7NO/c12-7-10-9-4-2-1-3-8(9)5-6-11-10/h1-7H

Upstream product

• 1721-93-3 1-methylisoquinoline 
• 540-80-7 tert.-butylnitrite 
• 2412-58-0 1-methyl-3,4,dihydroisoquinoline 
• 27311-63-3 1-Hydroxymethyl-isoquinoline 
• 88237-16-5 1-dichloromethylisoquinoline 
• 491-30-5 1-isoquinolone 
• 19493-44-8 1-chloroisoquinoline 
• 170486-98-3 1-(1,3-dioxolan-2-yl)isoquinoline 
• 119-65-3 isoquinoline 
• 20461-86-3 2,2-diethoxy acetic acid 
• 1532-71-4 1-bromoisoquinoline 
• 68-12-2 N,N-dimethyl-formamide 
• 486-73-7 1-isoquinolinecarboxylic acid 
• 27104-72-9 methyl isoquinoline-1-carboxylate 

Downstream Products

• 120745-82-6 [1,3]dioxolo[4,5-h]isoquino[2,1-b]isoquinolinylium; picrate 
• 111588-45-5 isoquino[3,2-a]isoquinolinylium; bromide 
• 27311-63-3 1-Hydroxymethyl-isoquinoline 
• 170486-99-4 1-(1,3-dioxolan-2-yl)-2-benzylisoquinolium bromide 
• 144163-92-8 1-(N-methylamino)methylisoquinoline 

Relevant articles and documents

Isoquinoline in the synthesis of 1-dichloromethylisoquinoline and 1-formylisoquinoline

By the reaction of isoquinoline with CCl4 and methanol catalyzed by iron-containing compounds a synthesis was performed of 1- dichloromethylisoquinoline that was quantitatively converted into 1-formylisoquinoline by the treatment with dimethyl sulfoxide. Pleiades Publishing, Ltd., 2010.

Metal-Free Chemoselective Oxidation of 4-Methylquinolines into Quinoline-4-Carbaldehydes

A convenient protocol for the synthesis of quinoline-4-carbaldehydes via chemoselective oxidation of 4-methylquinolines using hypervalent iodine(III) reagents as oxidant is described. This method highlights metal-free and mild reaction conditions, nice yield, good functional group tolerance, and high chemoselectivity.

NNYTHIOSEMICARBAZONE COMPOUNDS AND USES THEREOF

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SMALL MOLECULE INHIBITORS OF A PROTEIN COMPLEX

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