144282-35-9

Basic information

• Product Name: 5-Azaspiro[2.4]heptan-7-aMine, 5-(phenylMethyl)-, (S)-
• Synonyms: 5-Azaspiro[2.4]heptan-7-aMine, 5-(phenylMethyl)-, (S)-;(7S)-5-(phenylMethyl)-5-Azaspiro[2.4]heptan-7-aMine;(S)-5-Benzyl-5-aza-spiro[2.4]hept-7-ylamine;(S)-5-benzyl-5-azaspiro[2.4]heptan-7-amine;(S)-7-AMINO-5-BENZYL-5-AZASPIRO[2.4]HEPTANE
• CAS NO: 144282-35-9
• Molecular Formula: C₁₃H₁₈N₂
• Molecular Weight: 202.29542
• Mol File: 144282-35-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Azaspiro[2.4]heptan-7-aMine, 5-(phenylMethyl)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Azaspiro[2.4]heptan-7-aMine, 5-(phenylMethyl)-, (S)-(144282-35-9)
• EPA Substance Registry System: 5-Azaspiro[2.4]heptan-7-aMine, 5-(phenylMethyl)-, (S)-(144282-35-9)

Safety Data

• Hazardous Substances Data: 144282-35-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Azaspiro[2.4]heptan-7-amine, 5-(phenylmethyl)-, (S)is used as an antidepressant medication for the treatment of major depressive disorder in adults. It is effective in increasing serotonin levels in the brain, which helps regulate mood and alleviate depressive symptoms.

Upstream product

• 144282-41-7 (S)-7-amino-5-benzyl-5-azaspiro[2.4]heptan-4-one 
• 180506-32-5 (R)-5-Benzyl-7-hydroxy-5-aza-spiro[2.4]heptan-4-one 
• 129306-05-4 ethyl 1-(2-bromoacetyl)cyclopropanecarboxylate 
• 331443-52-8 N-benzyl-1-(2-bromoacetyl)cyclopropanecarboxamide 
• 147011-39-0 1-acetyl-N-[benzyl]cyclopropane-1-carboxamide 
• 882-36-0 N-benzyl-3-oxobutanamide 
• 129306-07-6 5-benzyl-5-azaspiro[2.4]heptane-7-amine 
• 129306-06-5 4-oxo-5-benzyl-7-hydroxyimino-5-azaspiro[2,4]heptane 
• 129306-04-3 5-benzyl-5-azaspiro[2.4]heptane-4,7-dione 

Downstream Products

• 1432056-70-6 5-benzyl-7(S)-tert-butoxycarbonylamino-5-azaspiro[2,4]heptane 
• 127199-45-5 (7S)-5-azaspiro[2.4]heptan-7-ylcarbamic acid tert-butyl ester 
• 127254-12-0 sitafloxacin 

Relevant articles and documents

Preparation method of sitafloxacin hydrate

The invention discloses a preparation method of sitafloxacin hydrate. The method comprises the following steps: taking ethyl 4-bromoacetoacetate used as a raw material, enabling ethyl 4-bromoacetoacetate to be fully reacted with 1,2-dibromoethane and preparing the obtained product into a compound II in the presence of carbonyl reduction enzyme; taking the compound II, enabling the compound II to carry out cyclization reaction with benzylamine in a solvent in the presence of cesium carbonate, enabling the obtained product to be reacted with DPPA and preparing a compound IV; reducing nitrine group of the compound IV to prepare a compound V; connecting primary amine group of the compound V with a BOC protection group to obtain a compound VI; reducing the compound VI through Pd/C, enabling theobtained product to be reacted with 8-chlorine-6,7-difluoro-1-[(1R,2s)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester to prepare a compound VIII; and carrying out deprotection of the compound VIII to obtain sitafloxacin hydrate. The sitafloxacin hydrate is few in preparation steps, simple in post-treatment and relatively high in yield.

A 5-benzyl -7 (S)-tert-butoxycarbonylamino-5-azaspiro [2,4] heptane preparation method of

The invention discloses a preparation method for 5-benzyl-7(S)-t-butyloxycarborylamino-5-aza-spiro[2,4]heptane. The method comprises the following steps: reacting benzoylamide acetoacetate as a raw material with 1,2-dichloroethane to obtain 3-cyclopropyl benzoylamide acetoacetate, brominating 3-cyclopropyl benzoylamide acetoacetate by NBS (n-bromosuccinimide) to obtain 1-bromo-3-cyclopropyl benzoylamide acetoacetate, cyclizing under alkaline conditions to obtain 5-benzyl-5-aza-spiro[2,4]heptane-4,7-diketone, further reacting with hydroxylamine hydrochloride to form an oxime compound-4-oxo-5-benzyl-7-oximido-5-aza-spiro[2,4]heptane, reducing by NaBH4 and boron trifluoride diethyl etherate to obtain 5-benzyl-7-amino-5-aza-spiro[2,4]heptane, performing chiral resolution by a resolving agent-L-camphorsulfonic acid to obtain 5-benzyl-7(S)-amino-5-aza-spiro[2,4]heptane, and reacting with di-tert-butyl dicarbonate ester to obtain 5-benzyl-7(S)-t-butyloxycarborylamino-5-aza-spiro[2,4]heptane. According to the method, an intermediate body-carbonyl does not need protection, raw materials are easy to get, a process route is simple, and the method is suitable for industrial production.

Process for the preparation of optically active amines or salts thereof

A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a) 1wherein R1 is typically an unsubstituted or substituted hydrocarbon group; and R2a is typically a hydrocarbon grou