144527-44-6

Basic information

• Product Name: (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride
• Synonyms: (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride;1-tert-Butyl 2-Methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxy
• CAS NO: 144527-44-6
• Molecular Formula: C₁₁H₁₉NO₅*ClH
• Molecular Weight: 281.7332
• Mol File: 144527-44-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride(144527-44-6)
• EPA Substance Registry System: (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride(144527-44-6)

Safety Data

• Hazardous Substances Data: 144527-44-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the modification and enhancement of the properties of other organic molecules, contributing to the development of new drugs with improved efficacy and safety profiles.
Used in Organic Synthesis:
In the field of organic synthesis, this compound serves as a versatile building block for the creation of complex organic molecules. Its reactivity and functional groups enable chemists to construct a wide range of chemical entities, including natural products, pharmaceuticals, and other bioactive molecules.
Used in Research and Development:
(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride is widely utilized in research and development settings due to its potential pharmacological activity. Researchers explore its applications in drug discovery, investigating its interactions with biological targets and evaluating its therapeutic potential in various disease models.
Used in Drug Discovery and Development:
(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride is employed as a promising candidate in drug discovery and development, particularly for its potential to be further modified and optimized for specific therapeutic applications. Its unique structural features and reactivity make it an attractive starting point for the design of novel drug molecules targeting various diseases and conditions.

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 

Downstream Products

• 154429-40-0 (2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid methyl ester 
• 114676-48-1 (2S,4R)-1-benzyl-4-hydroxyproline methyl ester 
• 88043-21-4 (2S,4R)-4-(toluene-4-sulfonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 

Relevant articles and documents

Efficient α-helix induction in a linear peptide chain by n-capping with a bridged-tricyclic diproline analogue

Secondary structure induction: The synthetic tricyclic amino acid ProM-5, which is formally created by stereoselective introduction of a vinylidene bridge into a di-proline unit, acts as a powerful scaffold to nucleate α-helix formation in a linear peptide chain. This might be exploited in the development of new proteomimetics for the modulation of protein interactions. Copyright