144620-11-1

Basic information

• Product Name: 3-(4-FLUORO-PHENYL)-PYRROLIDINE
• Synonyms: 3-(4-FLUORO-PHENYL)-PYRROLIDINE;3-(4-fluorophenyl)pyrrolidine(SALTDATA: FREE);4-(Pyrrolidin-3-yl)fluorobenzene;CHEMBRDG-BB 4006409;Pyrrolidine, 3-(4-fluorophenyl)-
• CAS NO: 144620-11-1
• Molecular Formula: C₁₀H₁₂FN
• Molecular Weight: 165.21
• Mol File: 144620-11-1.mol

Chemical Properties

• Boiling Point: 241.8°C at 760 mmHg
• Flash Point: 100°C
• Appearance: /
• Density: 1.078g/cm³
• Vapor Pressure: 0.0352mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.06±0.10(Predicted)
• CAS DataBase Reference: 3-(4-FLUORO-PHENYL)-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-FLUORO-PHENYL)-PYRROLIDINE(144620-11-1)
• EPA Substance Registry System: 3-(4-FLUORO-PHENYL)-PYRROLIDINE(144620-11-1)

Safety Data

• Statements: 52
• Hazardous Substances Data: 144620-11-1(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry and Pharmaceutical Research:
3-(4-FLUORO-PHENYL)-PYRROLIDINE is used as a potential drug candidate for its range of pharmacological activities, making it a valuable asset in the development of new therapeutic agents for various medical conditions.
Used in Organic Synthesis:
3-(4-FLUORO-PHENYL)-PYRROLIDINE is used as a building block in the synthesis of other organic compounds, contributing to the advancement of new materials and technologies in the chemical industry.
Used in Drug Development:
3-(4-FLUORO-PHENYL)-PYRROLIDINE is utilized in the development of new drugs, leveraging its pharmacological properties to address unmet medical needs and improve patient outcomes.

InChI:InChI=1/C10H12FN/c11-10-3-1-8(2-4-10)9-5-6-12-7-9/h1-4,9,12H,5-7H2

Upstream product

• 220474-60-2 1-benzyl-3-(4'-fluorophenyl)pyrrolidine 
• 1493-23-8 (4-fluorophenyl)lithium 

Downstream Products

• 231622-39-2 2-{4-[3-(4-fluoro-phenyl)-pyrrolidin-1-yl]-butyl}-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one 
• 1208147-27-6 C₂₈H₂₁Cl₂FN₄O 
• 1263285-96-6 tert-butyl 3-(4-fluorophenyl)pyrrolidine-1-carboxylate 
• 1219832-96-8 C₂₄H₂₁Cl₂FN₄O 
• 1201986-55-1 ((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)((2S,4R)-4-(fluorophenyl)pyrrolidin-2-yl)methanone hydrochloride 
• 1201987-30-5 (2S,4R)-tert-butyl 4-(4-fluorophenyl)-2-((R)-3-(4-fluorophenyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate 
• 1201986-72-2 (R)-tert-butyl 3-(4-fluorophenyl)pyrrolidine-1-carboxylate 
• 1048703-18-9 (R)-3-(4-fluoro-phenyl)-pyrrolidine 

Relevant articles and documents

N-Substituted-3-arylpyrrolidines: Potent and Selective Ligands at Serotonin 1A Receptor

3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for several selected compounds indicated that they are potentially effective antianxiety and antidepressant agents.