- NITRATION OF AROMATIC COMPOUNDS
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The present invention provides a process for nitrating aromatic compounds without the need for a solid catalyst and/or any organic solvents and/or any other additives. A typical process includes combining or admixing a nitric acid and an anhydride compound under conditions sufficient to produce a reactive intermediate. The aromatic compound to be nitrated is then added to this reactive intermediate to produce a nitroaromatic compound. The nitroaromatic compound can be substituted with one or more, typically, one to three, and often one or two nitrate (-NO2) groups.
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Paragraph 0041; 0043
(2016/08/17)
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- Synthesis of 13C and 15N labeled 2,4-dinitroanisole
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Syntheses of [13C6]-2,4-dinitroanisole (ring- 13C6) from [13C6]-anisole (ring-13C6) and [15N2]-2,4- dinitroanisole from anisole using in situ generated acetyl nitrate and [ 15N]-acetyl nitrate, respectively, are described. Treatment of [ 13C6]-anisole (ring-13C6) with acetyl nitrate generated in 100% HNO3 gave [13C 6]-2,4-dinitroanisole (ring-13C6) in 83% yield. Treatment of anisole with [15N]-acetyl nitrate generated in 10 N [15N]-HNO3 gave [15N2]-2,4- dinitroanisole in 44% yield after two cycles of nitration. Byproducts in the latter reaction included [15N]-2-nitroanisole and [ 15N]-4-nitroanisole.
- Jagadish, Bhumasamudram,Field, Jim A.,Chorover, Jon,Sierra-Alvarez, Reyes,Abrell, Leif,Mash, Eugene A.
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p. 434 - 436
(2014/07/07)
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- Synthesis of [13C6]primaquine
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In support of a program to identify toxic metabolites of the antimalarial, primaquine, its [13C6] analog was prepared from [ 13C6] anisole in seven steps. Copyright
- Herath, H. M. T. Bandara,McChesney, James D.,Walker, Larry A.,Nanayakkara, N. P. Dhammika
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p. 341 - 343
(2013/07/26)
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