145100-50-1

Basic information

• Product Name: 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE
• Synonyms: 2-[N,N-Bis(trifluoromethanesulphonyl)ami;N-(2-Pyridyl)bis(trifluoromethanesulfonimide) [Triflating Reagent];N-(2-Pyridyl)bis(trifluoroethanesulfonimide);N-(2-PYRIDYL)BIS(TRIFLUOROMETHANESULFONIMIDE);N,N-BIS(TRIFLUOROMETHYLSULFONYL)-2-PYRIDYLAMINE;2-PYRIDYLTRIFLIMIDE;2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]PYRIDINE;2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE
• CAS NO: 145100-50-1
• Molecular Formula: C₇H₄F₆N₂O₄S₂
• Molecular Weight: 358.24
• Mol File: 145100-50-1.mol

Chemical Properties

• Melting Point: 40-42 °C(lit.)
• Boiling Point: 80-90 °C0.25 mm Hg(lit.)
• Flash Point: 230 °F
• Appearance: White to almost white/Crystalline Powder or Crystals
• Density: 1.7255 (estimate)
• Vapor Pressure: 0.00024mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: Refrigerator (+4°C)
• PKA: -5.98±0.10(Predicted)
• Water Solubility: Hydrolyzes in water.
• Sensitive: Moisture Sensitive
• BRN: 5832565
• CAS DataBase Reference: 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE(145100-50-1)
• EPA Substance Registry System: 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE(145100-50-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 9
• Hazardous Substances Data: 145100-50-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE is used as an intermediate in the synthesis of aryl triflates and vinyl triflates. Its application in this context is due to its ability to act as a triflating reagent, which is crucial for the formation of these specific chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE is used as a reagent for the synthesis of various drug candidates. Its role in this industry is to facilitate the creation of new molecules with potential therapeutic properties, contributing to the development of novel medications.
Used in Research and Development:
2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE is also utilized in research and development settings, where it is employed to study the properties and reactivity of triflating reagents. This helps scientists understand the underlying mechanisms of various chemical reactions and develop new strategies for synthesizing complex molecules.

InChI:InChI=1/C7H4F6N2O4S2/c8-6(9,10)20(16,17)15(5-3-1-2-4-14-5)21(18,19)7(11,12)13/h1-4H

Upstream product

• 504-29-0 2-aminopyridine 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 197841-65-9 (2S,3S,6R)-6-(4-Benzyloxy-butyl)-2-(3-chloro-propyl)-3-methyl-4-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 274908-64-4 Ethyl (Z)-4-[tert-butyl(diphenyl)siloxy]-3-{[(trifluoromethyl)sulfonyl]oxy}but-2-enoate 
• 274908-76-8 Ethyl (E)-4-[tert-butyl(diphenyl)siloxy]-3-{[(trifluoromethyl)sulfonyl]oxy}but-2-enoate 
• 794517-26-3 Trifluoro-methanesulfonic acid (3R,4R,5R)-4,5-bis-benzyloxy-5-((2S,5R)-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3-methyl-1-methylene-pentyl ester 
• 856252-78-3 trifluoro-methanesulfonic acid 5-tert-butyl-2-formyl-phenyl ester 
• 182136-14-7 4-[[[[5,6-Dihydro-5,5-dimethyl-8-(trifluoro-methanesulfonyloxy)]-2-napthalenyl]carbonyl]amino]benzoic acid, methyl ester 
• 1076068-49-9 C₁₆⁽¹³⁾CH₁₅F₃O₄S 
• 1076068-47-7 C₁₇H₁₅F₃O₄S 
• 1045814-88-7 (4aS,9aS)-5-methoxy-4a-(3-methoxyphenyl)-1-(4-(tri-iso-propylsilyl)but-3-ynyl)-2,4a,9,9a-tetrahydro-1H-indeno[2,1-b]pyridin-3-yl-trifluoromethanesulfonate 
• 1190757-79-9 7-phenyl-1-hepten-6-yn-2-yl triflate 
• 1227628-62-7 C₁₈H₂₃F₃O₅S 

Relevant articles and documents

Retinoid-like compounds

The present invention relates to a compound of formula I STR1 or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in whichX is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH 2 --, --CH 2 --CH 2 --, --C C--, --CH 2 --NH--, --COCH 2 --, --NHCS--, --CH 2 S--, --CH 2 O--, --OCH 2 --, --NHCH 2 -- or --CR 5 CR 6 --;R m and R k are independently hydrogen, halogen, C 1-6 alkyl, hydroxy, C 1-6 alkyloxy or nitro;n is zero or one;R 4 is --(CH 2) t --Y, C 1-6 alkyl, or C 3-6 cycloalkyl;R 1 is --CO 2 Z, C 1-6 alkyl, CH 2 OH, --CONHR y, or CHO;R 2 and R 3 are independently hydrogen or C 1-6 alkyl;R a and R b are independently hydrogen or C 1-6 alkyl; but when n is one, R a and R b together can form a radical of the formula STR2 Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C 1-6 alkyl or halogen;Z is hydrogen or C 1-6 alkyl;R 5, R 6 and R y are independently hydrogen or C 1-6 alkyl; andt is zero to six.

Retinoid-like compounds

The present invention relates to a compound of formula STR1 or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which X is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH2 --, --CH2 --CH2 --, --C C--, --CH2 --NH--, --COCH2 --, --NHCS--, --CH2 S--, --CH2 O--, --OCH2 --, --NHCH2 -- or --CR5 =CR6 --; Rm and Rk are independently hydrogen, halogen, C1-6 alkyl, hydroxy, C1-6 alkyloxy or nitro; n is zero or one; R4 is --(CH2)t --Y, C1-6 alkyl, or C3-6 cycloalkyl; R1 is --CO2 Z, C1-6 alkyl, CH2 OH, --CONHRy, or CHO; R2 and R3 are independently hydrogen or C1-6 alkyl; Ra and Rb are independently hydrogen or C1-6 alkyl; but when n is one, Ra and Rb together can form a radical of the formula STR2 Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C1-6 alkyl or halogen; Z is hydrogen or C1-6 alkyl; R5, R6 and Ry are independently hydrogen or C1-6 alkyl; and t is zero to six.

Retinoid-like heterocycles

This invention relates to a compound of formula I STR1 in which T is --CONH-- or --CH CH--;R a and R b are independently C 1-6 alkyl;R c is C 1-6 alkyl or hydrogen; andR is heteroaryl and these compounds are useful in preventing and treating skin disorder

Pyridine-Derived Triflating Reagents: An Improved Preparation of Vinyl Triflates from Metallo Enolates.

Metallo enolates of ketones are trapped with an N-(2-pyridyl)triflimide at low temperatures to give vinyl triflates.