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2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE, also known as N-(2-Pyridyl)bis(trifluoromethanesulfonimide), is a chemical compound that serves as a useful triflating reagent. It is synthesized by reacting 2-aminopyridine and triflic anhydride and is characterized by its ability to transfer trifluoromethylsulfonyl (triflyl) groups in chemical reactions.

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  • 145100-50-1 Structure
  • Basic information

    1. Product Name: 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE
    2. Synonyms: 2-[N,N-Bis(trifluoromethanesulphonyl)ami;N-(2-Pyridyl)bis(trifluoromethanesulfonimide) [Triflating Reagent];N-(2-Pyridyl)bis(trifluoroethanesulfonimide);N-(2-PYRIDYL)BIS(TRIFLUOROMETHANESULFONIMIDE);N,N-BIS(TRIFLUOROMETHYLSULFONYL)-2-PYRIDYLAMINE;2-PYRIDYLTRIFLIMIDE;2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]PYRIDINE;2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE
    3. CAS NO:145100-50-1
    4. Molecular Formula: C7H4F6N2O4S2
    5. Molecular Weight: 358.24
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 145100-50-1.mol
  • Chemical Properties

    1. Melting Point: 40-42 °C(lit.)
    2. Boiling Point: 80-90 °C0.25 mm Hg(lit.)
    3. Flash Point: 230 °F
    4. Appearance: White to almost white/Crystalline Powder or Crystals
    5. Density: 1.7255 (estimate)
    6. Vapor Pressure: 0.00024mmHg at 25°C
    7. Refractive Index: 1.485
    8. Storage Temp.: Refrigerator (+4°C)
    9. Solubility: N/A
    10. PKA: -5.98±0.10(Predicted)
    11. Water Solubility: Hydrolyzes in water.
    12. Sensitive: Moisture Sensitive
    13. BRN: 5832565
    14. CAS DataBase Reference: 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE(CAS DataBase Reference)
    15. NIST Chemistry Reference: 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE(145100-50-1)
    16. EPA Substance Registry System: 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE(145100-50-1)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36
    4. WGK Germany: 3
    5. RTECS:
    6. F: 9
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 145100-50-1(Hazardous Substances Data)

145100-50-1 Usage

Uses

Used in Chemical Synthesis:
2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE is used as an intermediate in the synthesis of aryl triflates and vinyl triflates. Its application in this context is due to its ability to act as a triflating reagent, which is crucial for the formation of these specific chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE is used as a reagent for the synthesis of various drug candidates. Its role in this industry is to facilitate the creation of new molecules with potential therapeutic properties, contributing to the development of novel medications.
Used in Research and Development:
2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE is also utilized in research and development settings, where it is employed to study the properties and reactivity of triflating reagents. This helps scientists understand the underlying mechanisms of various chemical reactions and develop new strategies for synthesizing complex molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 145100-50-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,1,0 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 145100-50:
(8*1)+(7*4)+(6*5)+(5*1)+(4*0)+(3*0)+(2*5)+(1*0)=81
81 % 10 = 1
So 145100-50-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H4F6N2O4S2/c8-6(9,10)20(16,17)15(5-3-1-2-4-14-5)21(18,19)7(11,12)13/h1-4H

145100-50-1 Well-known Company Product Price

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  • Alfa Aesar

  • (L17433)  2-[N,N-Bis(trifluoromethylsulfonyl)amino]pyridine, 98%   

  • 145100-50-1

  • 1g

  • 433.0CNY

  • Detail
  • Alfa Aesar

  • (L17433)  2-[N,N-Bis(trifluoromethylsulfonyl)amino]pyridine, 98%   

  • 145100-50-1

  • 5g

  • 1448.0CNY

  • Detail
  • Aldrich

  • (403636)  N-(2-Pyridyl)bis(trifluoromethanesulfonimide)  96%

  • 145100-50-1

  • 403636-5G

  • 1,191.06CNY

  • Detail

145100-50-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2-Pyridyl)bis(trifluoromethanesulfonimide)

1.2 Other means of identification

Product number -
Other names 2-[N,N-Bis(trifluoromethylsulfonyl)amino]pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:145100-50-1 SDS

145100-50-1Downstream Products

145100-50-1Relevant articles and documents

Retinoid-like compounds

-

, (2008/06/13)

The present invention relates to a compound of formula I STR1 or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in whichX is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH 2 --, --CH 2 --CH 2 --, --C C--, --CH 2 --NH--, --COCH 2 --, --NHCS--, --CH 2 S--, --CH 2 O--, --OCH 2 --, --NHCH 2 -- or --CR 5 CR 6 --;R m and R k are independently hydrogen, halogen, C 1-6 alkyl, hydroxy, C 1-6 alkyloxy or nitro;n is zero or one;R 4 is --(CH 2) t --Y, C 1-6 alkyl, or C 3-6 cycloalkyl;R 1 is --CO 2 Z, C 1-6 alkyl, CH 2 OH, --CONHR y, or CHO;R 2 and R 3 are independently hydrogen or C 1-6 alkyl;R a and R b are independently hydrogen or C 1-6 alkyl; but when n is one, R a and R b together can form a radical of the formula STR2 Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C 1-6 alkyl or halogen;Z is hydrogen or C 1-6 alkyl;R 5, R 6 and R y are independently hydrogen or C 1-6 alkyl; andt is zero to six.

Retinoid-like compounds

-

, (2008/06/13)

The present invention relates to a compound of formula STR1 or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which X is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH2 --, --CH2 --CH2 --, --C C--, --CH2 --NH--, --COCH2 --, --NHCS--, --CH2 S--, --CH2 O--, --OCH2 --, --NHCH2 -- or --CR5 =CR6 --; Rm and Rk are independently hydrogen, halogen, C1-6 alkyl, hydroxy, C1-6 alkyloxy or nitro; n is zero or one; R4 is --(CH2)t --Y, C1-6 alkyl, or C3-6 cycloalkyl; R1 is --CO2 Z, C1-6 alkyl, CH2 OH, --CONHRy, or CHO; R2 and R3 are independently hydrogen or C1-6 alkyl; Ra and Rb are independently hydrogen or C1-6 alkyl; but when n is one, Ra and Rb together can form a radical of the formula STR2 Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C1-6 alkyl or halogen; Z is hydrogen or C1-6 alkyl; R5, R6 and Ry are independently hydrogen or C1-6 alkyl; and t is zero to six.

Retinoid-like heterocycles

-

, (2008/06/13)

This invention relates to a compound of formula I STR1 in which T is --CONH-- or --CH CH--;R a and R b are independently C 1-6 alkyl;R c is C 1-6 alkyl or hydrogen; andR is heteroaryl and these compounds are useful in preventing and treating skin disorder

Pyridine-Derived Triflating Reagents: An Improved Preparation of Vinyl Triflates from Metallo Enolates.

Comins, Daniel L.,Dehghani, Ali

, p. 6299 - 6302 (2007/10/02)

Metallo enolates of ketones are trapped with an N-(2-pyridyl)triflimide at low temperatures to give vinyl triflates.

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