145225-02-1 Usage
Uses
Used in Pharmaceutical Research:
Oxycodone-N-methyl-d3 Hydrochloride is used as a research compound for studying the pharmacokinetics, metabolism, and mechanism of action of Oxycodone. The deuterium labeling allows for easier detection and tracking of the molecule in biological systems, providing valuable insights into its behavior and potential interactions with other substances.
Used in Forensic Analysis:
In the field of forensic science, Oxycodone-N-methyl-d3 Hydrochloride is used as a reference material for the identification and quantification of Oxycodone in biological samples. The stable isotope labeling helps to differentiate the compound from its metabolites and other substances, ensuring accurate and reliable results in forensic investigations.
Used in Drug Development:
Oxycodone-N-methyl-d3 Hydrochloride is utilized as a tool in the development of new drugs targeting the same receptors as Oxycodone. By studying the interactions of the labeled compound with these receptors, researchers can gain a better understanding of the structure-activity relationships and design more effective and safer analgesic medications.
Used in Toxicology Studies:
In toxicology, Oxycodone-N-methyl-d3 Hydrochloride is used as an internal standard for the quantification of Oxycodone and its metabolites in toxicological analyses. The stable isotope labeling ensures accurate measurements and helps to determine the concentration of the drug in biological samples, which is crucial for understanding its toxic effects and potential for abuse.
Used in Drug Testing:
Oxycodone-N-methyl-d3 Hydrochloride is employed as a calibration standard in drug testing laboratories. The labeled compound is used to establish the accuracy and precision of analytical methods for detecting and measuring Oxycodone in various matrices, such as blood, urine, and hair samples. This helps to ensure the reliability of drug testing results and supports the enforcement of drug control policies.
Check Digit Verification of cas no
The CAS Registry Mumber 145225-02-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,2,2 and 5 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 145225-02:
(8*1)+(7*4)+(6*5)+(5*2)+(4*2)+(3*5)+(2*0)+(1*2)=101
101 % 10 = 1
So 145225-02-1 is a valid CAS Registry Number.
145225-02-1Relevant articles and documents
Electrochemical N-Demethylation of 14-Hydroxy Morphinans: Sustainable Access to Opioid Antagonists
Cantillo, David,Glotz, Gabriel,Kappe, C. Oliver
, p. 6891 - 6896 (2020)
The most challenging step in the preparation of many opioid antagonists is the selective N-demethylation of a 14-hydroxymorphinan precursor. This process is carried out on a large scale using stoichiometric amounts of hazardous chemicals like cyanogen bromide or chloroformates. We have developed a mild reagent- and catalyst-free procedure for the N-demethylation step based on the anodic oxidation of the tertiary amine. The ensuing intermediates can be readily hydrolyzed to the target nor-opioids in very good yields.
