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1455036-18-6

3-(5-amino-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1455036-18-6 Structure

  • Basic information

    1. Product Name: 3-(5-amino-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine
    2. Synonyms: 3-(5-amino-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine
    3. CAS NO:1455036-18-6
    4. Molecular Formula:
    5. Molecular Weight: 398.508
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1455036-18-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(5-amino-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(5-amino-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine(1455036-18-6)
    11. EPA Substance Registry System: 3-(5-amino-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine(1455036-18-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1455036-18-6(Hazardous Substances Data)

1455036-18-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1455036-18-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,5,0,3 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1455036-18:
(9*1)+(8*4)+(7*5)+(6*5)+(5*0)+(4*3)+(3*6)+(2*1)+(1*8)=146
146 % 10 = 6
So 1455036-18-6 is a valid CAS Registry Number.

1455036-18-6Relevant articles and documents

Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3- d ]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells

Henry, James R.,Kaufman, Michael D.,Peng, Sheng-Bin,Ahn, Yu Mi,Caldwell, Timothy M.,Vogeti, Lakshminarayana,Telikepalli, Hanumaiah,Lu, Wei-Ping,Hood, Molly M.,Rutkoski, Thomas J.,Smith, Bryan D.,Vogeti, Subha,Miller, David,Wise, Scott C.,Chun, Lawrence,Zhang, Xiaoyi,Zhang, Youyan,Kays, Lisa,Hipskind, Philip A.,Wrobleski, Aaron D.,Lobb, Karen L.,Clay, Julia M.,Cohen, Jeffrey D.,Walgren, Jennie L.,McCann, Denis,Patel, Phenil,Clawson, David K.,Guo, Sherry,Manglicmot, Danalyn,Groshong, Chris,Logan, Cheyenne,Starling, James J.,Flynn, Daniel L.

, p. 4165 - 4179 (2015/06/08)

The RAS-RAF-MEK-MAPK cascade is an essential signaling pathway, with activation typically mediated through cell surface receptors. The kinase inhibitors vemurafenib and dabrafenib, which target oncogenic BRAF V600E, have shown significant clinical efficac

RAF INHIBITOR COMPOUNDS

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Page/Page column 49, (2013/09/26)

This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.

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