1455091-04-9

Basic information

• Product Name: methyl2-(chloromethyl)-4-phenoxybenzoate
• Synonyms: methyl2-(chloromethyl)-4-phenoxybenzoate
• CAS NO: 1455091-04-9
• Molecular Formula: C₁₅H₁₃ClO₃
• Molecular Weight: 276.71492
• Mol File: 1455091-04-9.mol

Chemical Properties

• Boiling Point: 407.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.226±0.06 g/cm3(Predicted)
• CAS DataBase Reference: methyl2-(chloromethyl)-4-phenoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl2-(chloromethyl)-4-phenoxybenzoate(1455091-04-9)
• EPA Substance Registry System: methyl2-(chloromethyl)-4-phenoxybenzoate(1455091-04-9)

Safety Data

• Hazardous Substances Data: 1455091-04-9(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Industry:
Methyl 2-(chloromethyl)-4-phenoxybenzoate is used as an insecticide and acaricide for controlling a wide range of pests in agriculture. Its mode of action involves disrupting the nervous system of insects and mites, leading to their paralysis and eventual death. This makes it a valuable tool for farmers and pest control professionals in protecting crops and ensuring a bountiful harvest.
Used in Crop Protection:
Methyl 2-(chloromethyl)-4-phenoxybenzoate is used as a key component in formulated products for crop protection. It is typically applied as a spray to effectively control pests and prevent damage to crops. Its broad-spectrum activity and effectiveness in controlling various pests make it an essential tool in maintaining crop health and productivity.

Upstream product

• 57830-14-5 5-phenoxy-3H-isobenzofuran-1-one 
• 67-56-1 methanol 
• 64169-34-2 5-bromophthalide 
• 108-95-2 phenol 

Downstream Products

• 1455091-10-7 4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester 
• 1455086-85-7 3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid 
• 1455086-87-9 3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid 
• 1455086-89-1 2-(S)-hydroxy-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid 
• 1455086-92-6 4-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid 
• 1455086-94-8 5-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]pentanoic acid 
• 1455086-95-9 3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-3-methylbutyric acid 
• 1455086-97-1 2-(S)-hydroxy-4-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid 
• 1421312-34-6 4-hydroxy-1-methyl-7-phenoxyisoquinolinyl-3-carboxylic acid methyl ester 
• 1455089-22-1 3-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid 
• 1455091-19-6 2-(S)-tert-butoxycarbonylamino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid 
• 1455087-02-1 2-(S)-amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid 
• 1455094-16-2 1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester 
• 1455089-85-6 3-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid 

Relevant articles and documents

Preparation method of isoquinoline derivative

Disclosed is a preparation method of an isoquinoline derivative. A preparation method of a compound represented by a general formula II, i.e., 4-hydroxy-1-methyl-7-phenoxy isoquinoline-3-formate, is provided, wherein substituent definitions are as defined in the specification. The preparation method comprises the following steps of: under an acidic condition, dissolving a compound shown as a structural formula III in dimethyl sulfoxide, catalyzing by a ferrous ion (Fe) catalyst, and oxidizing by H2O2 to obtain the 4-hydroxy-1-methyl- 7-phenoxy isoquinoline-3-formate shown as the structuralformula II. By using the method, the production efficiency can be greatly improved, the production cost is reduced, the product purity can be ensured, and the method is suitable for industrial mass production.

IMPROVED PROCESS FOR THE PREPARATION OF ROXADUSTAT

A synthetic route for the preparation of Roxadustat, or a pharmaceutically acceptable salt thereof. Each route involves several novel intermediates and avoids the use of column chromatography.

Isoquinolone compound and application thereof

The invention relates to an isoquinolone compound and application thereof. The invention in particular relates to an isoquinolone compound used as a HIF prolyl hydroxylase inhibitor (HIF-PHI) and a pharmaceutical composition thereof. Moreover, the present invention provides the application of the isoquinolinone compound or the pharmaceutical composition thereof in the preparation of a medicament for preventing or treating HIF-associated or HIF-mediated diseases as anemia or ischemia, local ischemia or hypoxia.

PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS

The present invention relates to methods for making isoquinoline compounds and the intermediate compounds achieved thereby. Such compounds can be used to prepare compounds and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).

4 -HYDROXY- ISOQUINOLINE COMPOUNDS AS HIF HYDROXYLASE INHIBITORS

The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.