- Synthesis method of 4-bromo-2-methoxybenzenesulfonyl chloride
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The invention relates to a synthesis method of 4-bromo-2-methoxybenzenesulfonyl chloride. The synthesis method comprises the following steps of: adding cuprous chloride into water, dropwise adding thionyl chloride at 0-10 DEG C, and reacting at room temperature for 16-24 hours to form a standby solution A; adding 4-bromine-2-methoxyaniline into an acidic solvent at 0-10 DEG C, dropwise adding a sodium nitrite solution into the 4-bromine-2-methoxyaniline acidic solution system under the condition of controlling the temperature at 0-10 DEG C, and reacting for 30 minutes to 1 hour while keeping the temperature at -5 DEG C to 0 DEG C to form a standby solution B; finally, slowly dropwise adding the standby solution B into the standby solution A under the condition of controlling the temperature at 0-10 DEG C, enable the standby solution B and the standby solution A to be fully mixed and react, then raising the temperature to the room temperature of 25 DEG C, reacting for 8-24 hours, then introducing ice water, performing DCM extraction, backwashing, drying and spin-drying, and then performing purifying to obtain the compound 4-bromo-2-methoxybenzenesulfonyl chloride.
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Paragraph 0030-0039
(2020/09/09)
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- COMPOUNDS
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A compound of formula (I), or a pharmaceutical salt thereof.
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Page/Page column 114
(2020/01/11)
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- NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS
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The invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.
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Page/Page column 47; 48
(2019/03/05)
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- PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS
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The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Re, Rf and Y are as defined in the specification. The compounds are partial or full agonists at the growth hormone secretagogue (GHS) receptors . Pharmaceutical compositions comprising the compounds, methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.
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Page/Page column 53
(2010/02/15)
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- Amino heterocyclyl inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
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The present invention relates to compounds with the formula (I), or a pharmaceutically acceptable salt thereof: The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) or formula (II) and methods of treating a condition that is mediated by the modulation of 11-β-hsd-1, the method comprising administering to a mammal an effective amount of a compound of formula (I) or formula (II).
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Page/Page column 32
(2010/02/12)
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- PHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS
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Compounds of the formula STR1 inhibit the activity of endothelin. The symbols are defined as follows: R 1, R 2 and R. sup.3 are each independently(a) hydrogen, except that R. sup.1 is other than hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z 1, Z 2 and Z. sup.3 ;(c) halo;(d) hydroxyl;(e) cyano; (f) nitro; (g)--C(O)H or--C(O)R 6 ;(h)--CO 2 H or--CO 2 R 6 ; (i)--SH,--S(O) n R 6,--S(O) m--OH,--S(O) m--OR 6,--O--S(O) m--R 6,--O--S(O) m OH or--O--S(O) m--OR. sup.6 ;(j)--Z. sup.4--NR 7 R 8 ; or (k)--Z 4--N(R 11--Z 5--NR 9 R 10 ; and the remaining symbols are as defined in the specification.
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