145915-29-3Relevant articles and documents
Synthesis method of 4-bromo-2-methoxybenzenesulfonyl chloride
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Paragraph 0030-0039, (2020/09/09)
The invention relates to a synthesis method of 4-bromo-2-methoxybenzenesulfonyl chloride. The synthesis method comprises the following steps of: adding cuprous chloride into water, dropwise adding thionyl chloride at 0-10 DEG C, and reacting at room temperature for 16-24 hours to form a standby solution A; adding 4-bromine-2-methoxyaniline into an acidic solvent at 0-10 DEG C, dropwise adding a sodium nitrite solution into the 4-bromine-2-methoxyaniline acidic solution system under the condition of controlling the temperature at 0-10 DEG C, and reacting for 30 minutes to 1 hour while keeping the temperature at -5 DEG C to 0 DEG C to form a standby solution B; finally, slowly dropwise adding the standby solution B into the standby solution A under the condition of controlling the temperature at 0-10 DEG C, enable the standby solution B and the standby solution A to be fully mixed and react, then raising the temperature to the room temperature of 25 DEG C, reacting for 8-24 hours, then introducing ice water, performing DCM extraction, backwashing, drying and spin-drying, and then performing purifying to obtain the compound 4-bromo-2-methoxybenzenesulfonyl chloride.
NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS
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Page/Page column 47; 48, (2019/03/05)
The invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.
Amino heterocyclyl inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
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Page/Page column 32, (2010/02/12)
The present invention relates to compounds with the formula (I), or a pharmaceutically acceptable salt thereof: The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) or formula (II) and methods of treating a condition that is mediated by the modulation of 11-β-hsd-1, the method comprising administering to a mammal an effective amount of a compound of formula (I) or formula (II).