145934-58-3

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 3-broMo-2-Methyl-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 3-broMo-2-Methyl-;3-BroMo-2-Methyl-1H-pyrrolo[2,3-b]pyridine
• CAS NO: 145934-58-3
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.05858
• Mol File: 145934-58-3.mol

Chemical Properties

• Melting Point: 160-161 °C
• Boiling Point: 343.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.68±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 5.95±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 3-broMo-2-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 3-broMo-2-Methyl-(145934-58-3)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 3-broMo-2-Methyl-(145934-58-3)

Safety Data

• Hazardous Substances Data: 145934-58-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1H-Pyrrolo[2,3-b]pyridine, 3-bromo-2-methylis used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structural features allow for the development of new drugs and drug candidates with potential therapeutic applications.
Used in Medicinal Chemistry:
1H-Pyrrolo[2,3-b]pyridine, 3-bromo-2-methylserves as a valuable tool in medicinal chemistry, where it can be utilized to explore the structure-activity relationships of various drug molecules. Its presence in drug candidates can provide insights into the design and optimization of novel therapeutic agents.
Used in Drug Discovery:
1H-Pyrrolo[2,3-b]pyridine, 3-bromo-2-methylmay have applications in drug discovery, where it can be employed to identify new lead compounds with potential therapeutic effects. Its unique structural properties can contribute to the development of innovative drug molecules.
Used in Research and Development:
This chemical compound is also used in research and development for the exploration of new materials and the advancement of organic synthesis techniques. Its unique features can inspire the creation of novel chemical entities with potential applications in various fields.

Upstream product

• 23612-48-8 2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 189089-83-6 1-benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 143141-23-5 1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine 
• 271-63-6 7-Azaindole 
• 744209-37-8 3-bromo-2-methyl-1-phenylsulfonylpyrrolo[2,3-b]pyridine 

Downstream Products

• 145933-94-4 3-Bromo-2-methyl-7-phenacyl-pyrrolo[2,3-b]pyridine hydrobromide 

Relevant articles and documents

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The present application provides a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof; method for manufacturing said compound, and its therapeutic uses. The present application further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF

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Reaction of bromomethylazoles and tosylmethyl isocyanide. A novel heterocyclization method for the synthesis of the core of marine alkaloids variolins and related azolopyrimidines

A novel and efficient synthesis of the pyrido[3′,2′:4,5] pyrrolo[1,2-c]pyrimidine system, the heterocyclic core of the variolin family of marine alkaloids, is described. The route involves the reaction of 3-bromo-2-(bromomethyl)pyrrolo[2,3-b]pyridine and tosylmethyl isocyanide (TosMIC) under phase-transfer conditions. This unprecedented reaction was also used to synthesize a series of new methoxycarbonyl azolopyrimidines by reaction of TosMIC with bromomethylindoles, bromomethylbenzimidazole, and bromomethylpyrazole. Hydrolysis and decarboxylation of 5-bromo-7- methoxycarbonylpyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine obtained by this heterocyclization process and installation of the pyrimidine moiety in the C5 position open an alternative approach to complete a total synthesis of variolin B.