189089-83-6

Basic information

• Product Name: 2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine;1-(benzenesulfonyl)-2-Methyl-1H-pyrrolo[2,3-b]pyridine;1-(Phenylsulphonyl)-2-Methyl-7-azaindole ;1H-Pyrrolo[2,3-b]pyridine, 2-Methyl-1-(phenylsulfonyl)-;1-(phenylsulfonyl)-2-methyl-7-azaindole
• CAS NO: 189089-83-6
• Molecular Formula: C₁₄H₁₂N₂O₂S
• Molecular Weight: 272.327
• EINECS: 200-258-5
• Product Categories: Heterocycle-Pyridine series
• Mol File: 189089-83-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 103-105℃
• Boiling Point: 477.5°C at 760 mmHg
• Flash Point: 242.6°C
• Appearance: /
• Density: 1.31
• Vapor Pressure: 2.79E-09mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine(189089-83-6)
• EPA Substance Registry System: 2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine(189089-83-6)

Safety Data

• Hazardous Substances Data: 189089-83-6(Hazardous Substances Data)

Usage

General Description

2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, also known as PTP1B inhibitor, is a chemical compound that has been studied for its potential pharmaceutical applications. It is a pyrrolopyridine derivative that is designed to inhibit protein tyrosine phosphatase 1B (PTP1B), an enzyme that plays a role in the regulation of insulin signaling and energy balance. By inhibiting PTP1B, this compound has the potential to improve insulin sensitivity and regulate glucose levels, making it a potential candidate for the treatment of type 2 diabetes and obesity. The chemical structure of 2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine makes it a promising target for further research and development as a potential therapeutic agent.

InChI:InChI=1/C14H12N2O2S/c1-11-10-12-6-5-9-15-14(12)16(11)19(17,18)13-7-3-2-4-8-13/h2-10H,1H3

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 271-63-6 7-Azaindole 
• 23612-48-8 2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 143141-23-5 1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 307951-54-8 3-bromo-2-bromomethyl-1-phenylsulfonylpyrrolo[2,3-b]pyridine 
• 1602486-94-1 1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene 
• 1602486-95-2 1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-fluorophenyl)-3-thienyl]perfluorocyclopentene 
• 1592848-00-4 1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene 
• 1602486-96-3 1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-methylphenyl)-3-thienyl]perfluorocyclopentene 
• 1592847-98-7 1-(1,2-dimethyl-7-azaindol-3-yl)-2-[2-methyl-5-(4-methoxyphenyl)-3-thienyl]perfluorocyclopentene 
• 943324-08-1 1-benzenesulfonyl-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine 
• 23612-48-8 2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 145934-58-3 3-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 744209-37-8 3-bromo-2-methyl-1-phenylsulfonylpyrrolo[2,3-b]pyridine 

Relevant articles and documents

7-AZAINDOLE-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMOURS

The compound 4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine and pharmaceutically usable salts and/or tautomers thereof. The use of this compound for the treatment of tumours, tumour growth, tumour metastases and/or AIDS.

Synthesis and photochromism of novel unsymmetrical diarylethenes with an azaindole unit

A new class of unsymmetrical photochromic diarylethenes with an azaindole moiety has been firstly synthesized. Their properties, including photochromism, crystal structure, as well as fluorescence, were investigated systematically. The azaindole was conne

7-Azaindole-3-acetic acid derivatives: Potent and selective CRTh2 receptor antagonists

High throughput screening identified a 7-azaindole-3-acetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a highly selective compound with good functional potency for inhibition of human eosinophil shape change in whole blood and oral bioavailability in the rat.