14597-26-3Relevant articles and documents
BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING SAME
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Paragraph 00787-00789, (2019/06/05)
Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1 ), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.
Transformations of dialkyl(4-hydroxy-2-butynyl)-(3-phenylallyl)ammonium bromides in an KOH aqueous solution or in the presence of powdered KOH
Chukhadjian,Gabrielyan,Chukhadjian,Shahkhatuni,Panosyan
experimental part, p. 418 - 424 (2012/01/13)
Under the action of a twofold excess of KOH and heating in aqueous solution, and also under the conditions of the Stevens rearrangement (with KOH powder and a small amount of methanol) dialkyl-(4-hydroxy-2-butynyl)(3- phenylallyl)ammonium bromides form dialkyl[4-(1-phenylallyl)-2,5-dihydro-2- furyl]amines. Rearrangement-cleavage reaction also occurs under the same conditions.
Aminomethylation of acetylene alcohols and their esters with gem-diamines catalyzed by complexes of d-transition and rare-earth metals
Shaibakova,Titova,Ibragimov,Dzhemilev
experimental part, p. 161 - 167 (2011/05/04)
An efficient synthetic procedure was developed for preparation of oxygen-containing propargylamines with high yields and selectivity by aminomethylation of propargyl alcohols and their esters with gem-diamines catalyzed by complexes and salts of d-transit
Convergent, short synthesis of the muscarinic superagonist iperoxo
Kloeckner, Jessica,Schmitz, Jens,Holzgrabe, Ulrike
experimental part, p. 3470 - 3472 (2010/08/20)
Up to now the availability of iperoxo, an important superagonist of the muscarinic acetylcholine receptors, was limited because the synthesis of its precursor, the iperoxo base, was characterized by low yields, laborious chromatography and low reproducibility. Here we report a robust convergent three-step synthesis by means of a Mannich reaction and nucleophilic substitution at the 3-nitro-Δ2-isoxazoline. The new route combines short reaction time, high reproducibility and an overall yield increased from 12% to 42%.
Design and synthesis of potent antileishmanial cycloalkylidene-substituted ether phospholipid derivatives
Calogeropoulou, Theodora,Angelou, Panagiotis,Detsi, Anastasia,Fragiadaki, Irene,Scoulica, Effie
, p. 897 - 908 (2008/12/20)
Two series of novel ether phospholipids (EPs) have been synthesized. The first includes cyclodecylidene-or cyclopentadecylidene-substituted EPs carrying N,N,N-trimethylammonium or N-methylpiperidino or N-methylmorpholino head groups. The second series enc
ABSOLUTE MOLECULAR WEIGHT POLYMERS AND METHODS FOR THEIR USE
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, (2008/06/13)
A process for preparing defined molecular weight polymers, particularly polyquaternary ammonium compounds, is disclosed. As the molecular weights of these compounds can be absolutely defined, rather than defined merely in terms of "number average molecular weight," these compounds are particularly useful as identification standards for other polymers which are made using conventional polymerization processes. The polyquaternary ammonium compounds described are further suitable for use as antimicrobial agents, particularly in ophthalmic compositions.
Absolute molecular weight polymers and methods for their use
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, (2008/06/13)
A process for preparing defined molecular weight polymers, particularly polyquaternary ammonium compounds, is disclosed. As the molecular weights of these compounds can be absolutely defined, rather than defined merely in terms of "number average molecular weight," these compounds are particularly useful as identification standards for other polymers which are made using conventional polymerization processes. The polyquaternary ammonium compounds described are further suitable for use as antimicrobial agents, particularly in ophthalmic compositions.
