A convergent one-pot synthesis of secondary amines via aza-Wittig reaction
Secondary amines are obtained in moderate-good yields by reduction of crude imines prepared from N-alkyltriethoxyiminophosphoranes and aldehydes via the aza-Wittig reaction. N-Alkyltriethoxyiminophosphoranes are synthesized by one-pot azidation of alkyl bromides followed by Staudinger reaction.
TRIETHYL PHOSPHITE IN ORGANIC SYNTHESIS. A FACILE, ONE-POT CONVERSION OF ALCOHOLS INTO AMINES
General protocols for converting primary, secondary, and tertiary alcohols into the corresponding primary amines are presented.
Zwierzak, Andrzej
p. 51 - 54
(2007/10/02)
Optimized procedures for one-pot conversion of alkyl bromides into amines via the Staudinger reaction
New optimized procedures for transforming primary and secondary alkyl bromides into the corresponding primary amine salts have been elaborated. Essential modifications of azidation and deprotection of intermediate triethoxyphosphine alkylimides resulted in substantial improvement of the overall yields. Conversion of ammonium tosylates and hydrochlorides into free amines in a nonaqueous medium is described.
Koziara,Zwierzak
p. 1063 - 1065
(2007/10/02)
A Facile One-Pot Transformation of Alkyl Bromides into Diethyl N-Alkylphosphoroamidates
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Koziara, A.
p. 473 - 475
(2007/10/02)
One-Pot Transformation of Alkyl Bromdes into Primary Amines via the Staudinger Reaction
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Koziara, Anna,Osowska-Pacewicka, Krystyna,Zawadzki, Stefan,Zwierzak, Andrzej
p. 202 - 204
(2007/10/02)
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