Synthesis, antimycobacterial and antibacterial activity of fluoroquinolone derivatives containing an 3-alkoxyimino-4-(cyclopropylanimo)methylpyrrolidine moiety
A series of novel fluoroquinolone derivatives containing an 3-alkoxyimino-4-(cyclopropylanimo)methylpyrrolidine moiety were designed, synthesized and evaluated for their biological activity. Our results revealed that 19b2 shows good activity against MTB H
TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
The present disclosure relates to compounds which modulate the activity of Toll-like receptor (TLR) proteins, including agonists or activators, partial agonists, and antagonists. Of particular interest of compounds that modulate the activity of TLR2, as well as methods of using such compounds to treat cancer and other disorders associated with a TLR2 pathway.
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Paragraph 00487-00488
(2021/12/08)
Peptides containing an arginine mimetic for the treatment of bone metabolic disorders, their production, and drugs containing these compounds
Arginine mimetic peptides according to Formula I of this application have a stimulating effect on bone formation and are useful for the treatment of bone metabolic disorders.
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(2008/06/13)
12-Helix formation in aqueous solution with short β-peptides containing pyrrolidine-based residues
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Wang, Xifang,Espinosa, Juan F.,Gellman, Samuel H.
p. 4821 - 4822
(2007/10/03)
Amidinopyrroline derivatives, processes for their production and pharmaceutical agents containing these compounds
Compound of formula (I) are disclosed STR1 as well as optically active isomers or pharmacologically acceptable salts thereof. The compounds are useful active ingredients in pharmaceutical compositions, and methods of treating osteoporosis, inflammation or
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(2008/06/13)
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