146328-85-0

Basic information

• Product Name: 5-Bromo-2-fluorobenzoic acid
• Synonyms: RARECHEM AL BO 0757;2-FLUORO-5-BROMOBENZOIC ACID;5-BROMO-2-FLUOROBENZOIC ACID;BUTTPARK 19\01-67;5-Bromo-2-Fluorobenzoic Acid 2-Fluoro-5-Bromobenzoic Acid;5-Bromo-2-fluorobenzoic;5-Bromo-2-fluorobenzoic acid 97%;5-Bromo-2-fluorobenzoicacid97%
• CAS NO: 146328-85-0
• Molecular Formula: C₇H₄BrFO₂
• Molecular Weight: 219.01
• EINECS: 604-519-9
• Product Categories: Fluorin-contained Benzoic acid series;blocks;Bromides;Carboxes;FluoroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Miscellaneous;Acids & Esters;Bromine Compounds;Fluorine Compounds;C7;Carbonyl Compounds;Carboxylic Acids;Benzoic acid series;Fluorine series
• Mol File: 146328-85-0.mol

Chemical Properties

• Melting Point: 141-145 °C(lit.)
• Boiling Point: 296.5 °C at 760 mmHg
• Flash Point: 133.1 °C
• Appearance: /
• Density: 1.789 g/cm³
• Vapor Pressure: 0.000644mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.88±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-Bromo-2-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-fluorobenzoic acid(146328-85-0)
• EPA Substance Registry System: 5-Bromo-2-fluorobenzoic acid(146328-85-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 146328-85-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-2-fluorobenzoic acid is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure allows for the creation of a wide range of medicinal compounds with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic chemistry, 5-Bromo-2-fluorobenzoic acid serves as an important intermediate for the synthesis of various organic compounds. Its bromine and fluorine substituents can be utilized in a variety of chemical reactions, enabling the production of diverse molecules with specific properties and functions.

InChI:InChI=1/C7H4BrFO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)/p-1

Upstream product

• 124-38-9 carbon dioxide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 445-29-4 o-fluoro-benzoic acid 

Downstream Products

• 146328-84-9 4-fluoro-[1,1'-biphenyl]-3-carboxylic acid 
• 773140-42-4 2-bromo-5-fluorobenzoyl chloride 
• 552331-21-2 (5-bromo-2-fluorophenyl)(1H-pyrrol-2-yl)methanone 
• 57381-59-6 methyl 2-fluoro-5-bromobenzoate 
• 453566-35-3 3-(pyridin-2-yl)-5-(5-bromo-2-fluorophenyl)-1,2,4-oxadiazole 
• 247569-37-5 5-bromo-N-(3,4-dimethoxybenzyl)-2-fluorobenzamide 
• 247568-34-9 2-fluoro-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247570-14-5 5-bromo-N-(4-chloro-3-methoxybenzyl)-2-fluorobenzamide 
• 940284-95-7 C₁₃H₁₇BrN₂O₂ 
• 935285-60-2 tert-butyl (5-bromo-2-fluorophenyl)carbamate 
• 847972-15-0 5-bromo-2-morpholinobenzoic acid 
• 1016511-69-5 N-(2-amino-phenyl)-5-bromo-2-fluoro-benzamide 
• 188723-78-6 5-bromo-2-fluoro-N,N-dimethylbenzamide 
• 1000782-10-4 tert-butyl 4-(5-bromo-2-fluorobenzoyl)-3-(hydroxymethyl)piperazine-1-carboxylate 

Relevant articles and documents

Synthesis method of 2-halo-5-bromobenzoic acid

The invention discloses a synthesis method of 2-halo-5-bromobenzoic acid. The method comprises the following steps of under the action of sulfuric acid, carrying out a bromination reaction on o-halo-benzoic acid and NBS in an organic solvent, and after the reaction is finished, carrying out posttreatment to obtain 2-halo-5-bromobenzoic acid. The method has the advantages of being short in reactionroute, simple in operation, environmentally friendly, safe and economical and has a broad application prospect.

Preparation method of 2,5-dihalo-benzoic acid

The invention discloses a preparation method of 2,5-dihalo-benzoic acid. The method comprises the following steps: concentrated sulfuric acid is added dropwise to a mixed solution containing sodium bromide, periodate and 2-halo-benzoic acid in presence of water and acetic acid, the mixed solution is subjected to a reaction, and 2,5-dihalo-benzoic acid is prepared. The problems of long time neededfor preparation, high reaction temperature and the like of the preparation method of 2,5-dihalo-benzoic acid in the prior art can be solved.

TRIAZOLONES DERIVATIVES FOR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, codrug, cocrystal, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

Synthesis and structural characterization of new phosphinooxazoline complexes of iron

The first phosphinooxazoline chelate complexes of iron were synthesized, and their structural and electronic properties were studied. The known phosphinooxazolines 2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole (7a), 2-(2-(diphenylphosphino)phenyl)-4,

Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitors

As a result of the various N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives with a hydroxy moiety synthesized in an effort to discover novel glycogen phosphorylase (GP) inhibitors, 5-chloro-N-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-indole-2

Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors

A series of heteroaryl-pyridine containing inhibitors of Akt are reported. The synthesis and structure-activity relationships are discussed, leading to the discovery of a indazole-pyridine analogue (Ki = 0.16 nM). These compounds bind in the ATP binding site, are potent, ATP competitive, and reversible inhibitors of Akt activity. No selectivity amongst the Akt isoforms is observed for this analogue, but there is good selectivity against an panel of other kinases. It is least selective for other members of the AGC family of kinases but is nonetheless 40-fold selective for Akt over PKA. The compound shows cellular activity and significantly slows tumor growth in vivo.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

Regioselective ortho-lithiation of chloro and bromo substituted fluoroarenes

Deprotonation of fluoroarenes carrying chlorine or bromine as additional substituents occurs always at a fluorine adjacent position if accomplished with potassium tert-butoxide activated butyllithium or lithium 2,2,6,6-tetramethylpiperidide.