146447-18-9

Basic information

• Product Name: 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
• Synonyms: 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE;5-BROMO-2-CHLORO-4-FLUOROANISOLE;5-Bromo-2-chloro-4-fluoro-1-methoxybenzene;Benzene,1-bromo-4-chloro-2-fluoro-5-methoxy-
• CAS NO: 146447-18-9
• Molecular Formula: C₇H₅BrClFO
• Molecular Weight: 239.47
• Mol File: 146447-18-9.mol

Chemical Properties

• Melting Point: 72.0 to 76.0 °C
• Boiling Point: 237.658 °C at 760 mmHg
• Flash Point: 97.533 °C
• Appearance: /
• Density: 1.643 g/cm³
• Vapor Pressure: 0.068mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE(146447-18-9)
• EPA Substance Registry System: 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE(146447-18-9)

Safety Data

• Hazard Codes: Xn
• Hazardous Substances Data: 146447-18-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene is used as a starting material in the production of various pharmaceuticals and agrochemicals. Its unique structure allows for the synthesis of a variety of compounds with different biological activities and properties.
Used in the Development of New Materials and Polymers:
1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene serves as a building block in the development of new materials and polymers. Its presence in these materials can impart specific characteristics, such as improved stability, enhanced properties, or novel functionalities.
Used in the Chemical Industry:
1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene is utilized in the chemical industry for various applications, including the synthesis of intermediates, catalysts, and other specialty chemicals. Its unique combination of functional groups makes it a valuable component in the development of innovative products and processes.

InChI:InChI=1/C7H5BrClFO/c1-11-7-2-4(8)6(10)3-5(7)9/h2-3H,1H3

Upstream product

• 91167-85-0 4-Chloro-2-fluoro-5-methoxyaniline 
• 2267-25-6 2-chloro-4-fluoro-1-methoxy-benzene 
• 330794-03-1 2-methoxy-4-bromo-5-fluoroaniline 
• 137110-49-7 (5-amino-2-chloro-4-fluorophenyl) ethyl carbonate 
• 153471-75-1 (2-chloro-4-fluoro-5-nitrophenyl) ethyl carbonate 
• 153406-19-0 (2-chloro-4-fluorophenyl) ethyl carbonate 
• 399-94-0 2-bromo-1,4-difluorobenzene 
• 330794-02-0 1-bromo-2-fluoro-5-methoxy-4-nitrobenzene 
• 167415-27-2 1-bromo-2,5-difluoro-4-nitrobenzene 
• 1996-41-4 2-chloro-4-fluorophenol 
• 148254-32-4 5-bromo-2-chloro-4-fluorophenol 
• 74-88-4 methyl iodide 

Downstream Products

• 740807-00-5 1-(4-Chloro-2-fluoro-5-methoxy-phenyl)-piperazine 

Relevant articles and documents

POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF

Provided are a polycyclic pyrazolinone derivative indicated by general formula (1) (in the formula, R1, X1, X2, X3, and Y indicate the definitions provided in the Specification) and a herbicide comprising same as effective component thereof.

PYRAZOLINE-3-ON DERIVATIVE AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT

PROBLEM TO BE SOLVED: To provide a compound having excellent weed controlling effect and useful as an active ingredient of a herbicide. SOLUTION: There are provided a pyrazoline-3-on derivative represented by the following formula (1), where R1

PYRAZOLINONE DERIVATIVE, MANUFACTURING METHOD THEREFOR AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT

PROBLEM TO BE SOLVED: To provide a compound having excellent weed controlling effect and useful as an active ingredient of a herbicide. SOLUTION: There are provided a pyrazolinone derivative represented by the formula (1), a manufacturing method therefor and herbicide containing the same. (1), where R1 is a halogen atom, R2 and R3 are integrally a trimethylene group (-(CH2)3-), a tetramethylene group (-(CH2)4-), a pentamethylene group (-(CH2)5-) or an oxydiethylene group (-(CH2)2O(CH2)2-), R4 is H or a halogen atom, R5 is a halogen atom, Ar is 3-oxo-1,4-benzoxazine-5-yl group, a 2,2-difluoro-3-oxo-1,4-benzoxazine-5-yl group or a 3,4-dihydro-2-oxo quinoxaline-5-yl group. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

A series of isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones were synthesized as potent inhibitors against Pim-1 and Pim-2 kinases. The structure-activity-relationship studies started from a high-throughput screening hit and was guided by molecular modeling of inhibitors in the active site of Pim-1 kinase. Installing a hydroxyl group on the benzene ring of the core has the potential to form a key hydrogen bond interaction to the hinge region of the binding pocket and thus resulted in the most potent inhibitor, 19, with Ki values at 2.5 and 43.5 nM against Pim-1 and Pim-2, respectively. Compound 19 also exhibited an activity profile with a high degree of kinase selectivity.

2-(POLY-SUBSTITUTED ARYL)-6-AMINO-5-HALO-4-PYRIMIDINECARBOXYLIC ACIDS AND THEIR USE AS HERBICIDES

6-Amino-5-halo-4-pyrirnidinecarboxylic acids having poly-substituted aryl substituents in the 2-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.

6-(Poly-substituted aryl)-4-aminopicolinates and their use as herbicides

4-Aminopicolinic acids having tri- and tetra-substituted aryl substituents in the 6-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.

Substituted piperazines

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.