- Synthesis, crystal structure and in vitro anticancer studies of bis(dibenzyldithiocarbamato)Zn(II)
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Bis(dibenzyldithiocarbamato)Zn(II), [Zn(dbzdtc)2], was synthesized and characterized by spectroscopic techniques, elemental analysis and single crystal X-ray crystallography. The compound is crystallized in a monoclinic space group P21/n with Zn(II) located on crystallographic twofold symmetry and coordinated to two molecules of dibenzyl dithiocarbamato anions to form a rare four-coordinate mononuclear Zn(II) complex in a see-saw geometry. The cytotoxicity of the complex was evaluated by MTT assay against breast cancer cells (MCF-7) and human embryonic kidney cells (HEK293). The results showed that the complex is active against MCF-7 breast cancer cells with IC50 value of 6.41 and 4.423?μΜ against HEK293 cell line.
- Ajibade, Peter A.,Sikakane, Berlinda M.,Oluwalana, Abimbola E.,Paca, Athandwe M.,Singh, Moganavelli
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- Structural, morphological and optical properties of iron sulfide, cobalt sulfide, copper sulfide, zinc sulfide and copper-iron sulfide nanoparticles synthesized from single source precursors
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Iron sulfide (1), cobalt sulfide (2), copper sulfide (3), zinc sulfide (4), and copper-iron sulfide (5) nanoparticles were prepared from [Fe(dbzdtc)3], [Co(dbzdtc)3], [Cu(dbzdtc)2], [Zn(dbzdtc)2] and [Cu(dbzdtc)3][FeCl4] (where dbzdtc = N,N-dibenzyldithiocarbamate), respectively. The synthesized samples 1–5 were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), UV–Vis, photoluminescence and Fourier transform infrared (FT-IR) spectroscopy techniques. In the X-ray diffraction patterns of samples 1, 3–5, sharp peaks are observed which indicates that the as-prepared metal sulfide nanoparticles, 1,3–5 are crystalline. EDAX spectra confirm the composition of the metal sulfides. The SAED spots of as-prepared copper sulfide and zinc sulfide supports the crystalline nature of the nanoparticles. UV–Vis absorption and photoluminescence spectra of the synthesized nanoparticles 1–5 show a significant blue shift compared to that of the respective bulk metal sulfide. Infrared spectral studies on metal sulfides (Samples 1,2,4 and 5) confirm the presence of capping agent ethylenediamine (en).
- Sathiyaraj,Thirumaran
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- Method for preparing crystal form thioamino carboxylate by taking secondary amine as raw material
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The invention relates to a method for preparing crystal form thioamino carboxylate by taking secondary amine as a raw material, namely a method for preparing the crystal form thioamino carboxylate bya one-step method through a mixed reaction of the secondary amine, carbon disulfide, metal oxide or hydroxide in water. According to the scheme, conventional reaction equipment and simplified raw materials are used for preparing a high-purity product; the method is low in water consumption, inorganic salt byproducts are not generated, and the reaction mother liquor can be recycled directly or through simple treatment.
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Paragraph 0053-0056
(2020/05/01)
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- Rubber vulcanization accelerator dibenzyl di-thio amino a acid zinc preparation method
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The invention relates to a preparation method of a rubber vulcanization accelerator zinc dibenzyl dithiocarbamate. The method comprises the following steps: adding a solution of dibenzylamine-xylene mixture into a container, and adding a surfactant, a catalyst and zinc oxide; heating to certain temperature, and dropwise adding carbon disulfide into the mixture; stirring and reacting for certain time, and filtering out the product zinc dibenzyl dithiocarbamate from the reaction mixture; adding water into the filtered product for azeotropic distillation with the water to obtain a high-purity product. The method is simple to operate; compared with the traditional preparation method, the reaction conditions are not harsh, the product has high purity, and the solvent is recycled to facilitate environmental protection; more importantly, by adding the catalyst, the reaction time is greatly shortened, and the reaction period is reduced.
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Paragraph 0023; 0024;
(2016/10/07)
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- Synthesis, spectral, thermal and BVS investigations on ZnS4N^N/N coordination environment: Single crystal X-ray structures of bis(dibenzyldithiocarbamato)(N^N)Zinc(II) complexes (N^N = 1,10-phenanthroline, tetramethylethylenediamine and 4,4′-bipyridine)
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The current paper describes the synthesis and spectral investigations on the adducts of [Zn(dbzdtc)2] (1) with 1,10-phen (2), tmed (3), 2,2′-bipy (4) and 4,4′-bipy (5) (where, dbzdtc = dibenzyldithiocarbamate anion, 1,10-phen = 1,10-phenanthroline, tmed = tetramethylethylenediamine, 2,2′-bipy = 2,2′-bipyridine, 4,4′-bipy = 4,4′-bipyridne) and single crystal X-ray structures of [Zn(dbzdtc)2(1,10-phen)] (2) and [Zn(dbzdtc)2(tmed)] (3) and [Zn(dbzdtc)2(4,4′-bipy)] (5). 1H and 13C NMR spectra of 1,10-phen, tmed, 2,2′-bipy and 4,4′-bipy adducts were recorded. 1H NMR spectra of the complexes show the drift of electrons from the nitrogen of the substituents forcing a high electron density towards sulfur via the thioureide π-system. In the 13C NMR spectra, the most important thioureide (N13CS2) carbon signals are observed in the region: 206-210 ppm. Fluorescence spectra of complexes (2) and (4) show intense fluorescence due to the presence of rigid conjugate systems such as 1,10-phenanthroline and 2,2′-bipyridine. The observed fluorescence maxima for complexes with an MS4N2 chromophore in the visible region are assigned to the metal-to-ligand charge transfer (MLCT) processes. Single crystal X-ray structural analysis of (2) and (3) showed that the zinc atom is in a distorted octahedral environment. Bond Valence Sum was found to be equivalent to 1.865 for (2), 1.681 for (3) supporting the correctness of the determined structure. BVS of (3) deviates from the formal oxidation number of zinc due to the non-aromatic, sterically hindering tetramethyl bonding end of tmed. Thermal studies on the compounds show the formation of Zn(NCS)2 as an intermediate during the decay.
- Marimuthu,Ramalingam,Rizzoli
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p. 1555 - 1560
(2010/06/20)
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