34409-33-1Relevant articles and documents
Synthesis and crystal structures of bis(dibenzyl dithiocarbamato)Cu(II) and Ag(I) complexes: Precursors for Cu1.8S and Ag2S nano-photocatalysts
Ajibade, Peter A.,Botha, Nandipha L.,Oluwalana, Abimbola E.,Omondi, Bernard,Sikakane, Berlinda M.
, (2020)
We report the synthesis and crystal structures of bis(dibenzyl dithiocarbamato) copper(II) and silver(I) complexes and their use as precursors to prepare Cu1.8S and Ag2S nanoparticles. Single crystal analysis of bis(dibenzyl dithiocarbamato)Cu(II) complex consist of a monomeric entity where the two dibenzyl dithiocarbamate ligands form a distorted square planar geometry around the Cu(II) ion. The bis(dibenzyl dithiocarbamato)Ag(I) formed hexameric coordination complex consisting of two distorted hexagonal Ag3S3 rings. The complexes were thermolysed at 220 °C to prepare copper sulphide and silver sulphide nanoparticles. Powder X-ray diffraction (p-XRD) patterns of the copper sulphide nanoparticles were indexed to digenite Cu1.8S, while silver sulphide nanoparticles were confirmed to be acathinite Ag2S. High-resolution transmission electron microscopy (HRTEM) images showed Ag2S nanoparticles with particle size in the range 11.4–27.4 nm while Cu1.8S nanoparticles are semi-spherical in shape with slightly agglomerated particles in the range 6.9–24.0 nm. The as-prepared nanoparticles were used as nano-photocatalysts for the degradation of methylene blue dye (MB) under UV light irradiation with degradation efficiency of 42.52% and 48.39% for Cu1.8S and Ag2S nanoparticles respectively.
Application of dibenzyl dithiocarbamate drug for treating tri-negative breast cancer
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Paragraph 0008-0009, (2021/09/29)
The invention relates to an application of a dibenzyl dithiocarbamate drug for treating three-negative breast cancer. The preparation method comprises the following steps: stirring in an ice water bath, stirring 0.06 μM mass of dibenzylamine and 11.8g of acetonitrile in an ice water bath, adding 150 ml mass of 0.09 μM carbon disulfide 6.96g and 6.96g, suction filtration, and rotary evaporation of the filtrate to obtain a product, and drying the product with diethyl ether to obtain the product 0.09 μM 16 hours. The method comprises the following steps: stirring reaction 13.04g 50% and carrying out suction filtration. The crude product is recrystallized from acetonitrile to obtain dibenzyl dithiocarbamate with a mass of 11.1g. On the basis of the disulfiram anti-cancer structure, the new drug dibenzyldithiocarbamate does not need to be converted in vivo, and the fat solubility is improved.
Structural, morphological and optical properties of iron sulfide, cobalt sulfide, copper sulfide, zinc sulfide and copper-iron sulfide nanoparticles synthesized from single source precursors
Sathiyaraj,Thirumaran
, (2019/12/09)
Iron sulfide (1), cobalt sulfide (2), copper sulfide (3), zinc sulfide (4), and copper-iron sulfide (5) nanoparticles were prepared from [Fe(dbzdtc)3], [Co(dbzdtc)3], [Cu(dbzdtc)2], [Zn(dbzdtc)2] and [Cu(dbzdtc)3][FeCl4] (where dbzdtc = N,N-dibenzyldithiocarbamate), respectively. The synthesized samples 1–5 were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), UV–Vis, photoluminescence and Fourier transform infrared (FT-IR) spectroscopy techniques. In the X-ray diffraction patterns of samples 1, 3–5, sharp peaks are observed which indicates that the as-prepared metal sulfide nanoparticles, 1,3–5 are crystalline. EDAX spectra confirm the composition of the metal sulfides. The SAED spots of as-prepared copper sulfide and zinc sulfide supports the crystalline nature of the nanoparticles. UV–Vis absorption and photoluminescence spectra of the synthesized nanoparticles 1–5 show a significant blue shift compared to that of the respective bulk metal sulfide. Infrared spectral studies on metal sulfides (Samples 1,2,4 and 5) confirm the presence of capping agent ethylenediamine (en).
Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells
Fujie, Tomoya,Murakami, Masaki,Yoshida, Eiko,Tachinami, Tadashi,Shinkai, Yasuhiro,Fujiwara, Yasuyuki,Yamamoto, Chika,Kumagai, Yoshito,Naka, Hiroshi,Kaji, Toshiyuki
, p. 263 - 273 (2016/03/30)
The interest in organic-inorganic hybrid molecules as molecular probes for biological systems has been growing rapidly. Such hybrid molecules exhibit unique biological activities. Herein, copper(II) bis(diethyldithiocarbamate) (Cu10) was found to activate the transcription factor NF-E2-related factor 2 (Nrf2), which is responsible for regulating antioxidant and phase II xenobiotic enzymes, in vascular endothelial cells. The copper complex rapidly accumulated within cells and induced nuclear translocation of Nrf2, leading to upregulation of the expression of downstream proteins without cytotoxic effects. However, while copper bis(2-hydroxyethyl)dithiocarbamate activated Nrf2, copper ion, diethyldithiocarbamate ligand with or without zinc or iron failed to exhibit this activity. Intracellular accumulation of Cu10 was higher than that of Cu(II) and Cu(I). While the accumulation of copper(II) bis(dimethyldithiocarbamate) was reduced by small interfering RNA (siRNA)-mediated knockdown of the copper transporter CTR1, the knockdown did not affect Cu10 accumulation, indicating that Cu10 rapidly enters vascular endothelial cells via CTR1-independent mechanisms. In addition, copper and iron complexes with other ligands tested could not activate Nrf2, suggesting that the intramolecular interaction between copper and dithiocarbamate ligand is important for the activation of the transcription factor. Cu10 induced the expression of heme oxygenase-1, NAD(P)H quinone oxidoreductase 1, and γ-glutamylcysteine synthetase, downstream proteins of Nrf2. It was suggested that Cu10-induced activation of Nrf2 was due to proteasome inhibition as well as binding to Kelch-like ECH-associated protein 1. Since the effects of Cu10 on vascular endothelial cells are unique and diverse, the copper complex may be a good molecular probe to analyze the functions of the cells.
Neutral and ionic complexes of C60 with metal dibenzyldithiocarbamates. Reversible dimerization of C60 ?- in ionic multicomponent complex [Crl(C 6H6)2?+]·(C 60?-)·0.5[Pd(dbdtc)2]
Konarev, Dmitri V.,Kovalevsky, Andrey Yu.,Otsuka, Akihiro,Saito, Gunzi,Lyubovskaya, Rimma N.
, p. 9547 - 9553 (2008/10/09)
New molecular complexes of C60 with metal(II) dibenzyldithiocarbamates, M(dbdtc)2·C60·0. 5(C6H5Cl), where M = CuII, NiII, PdII, and PtII (1-4) and an ionic multicomponent complex [Crl(C6H6)2?+] ·(C60?-)·0.5[Pd(dbdtc)2] (5) (Cr-(C6H6)S: bis(benzene)chromium) were obtained. According to IR, UV-visible-NIR, and EPR spectra, 1-4 involve neutral components, whereas 5 comprises neutral Pd(dbdtc)2 and C 60?- and Crl(C6H 6)2?+ radical ions. The crystal structure of 5 at 90 K reveals strongly puckered fullerene layers alternating with those composed of Pd(dbdtc)2. The Crl(C6H 6)2?+ radical cations are arranged between the layers. Fullerene radical anions form pairs within the layer with an interfullerene C...C contact of 3.092(2) A, indicating their monomeric state at 90 K. This contact is essentially shorter than the sum of van der Waals radii of two carbon atoms, and consequently, C60 ?- can dimerize. According to SQUID and EPR, single-bonded diamagnetic (C60-)2 dimers form in 5 below 150-130 K on slow cooling and dissociate above 150-170 K on heating. The hysteresis was estimated to be 20 K. For the (C60-) 2 dimers in 5, the dissociation temperature is the lowest among those for ionic complexes of C60 (160-250 K). Fast cooling of the crystals within 10 min from room temperature down to 100 K shifts dimerization temperatures to lower than 60 K. This shift is responsible for the retention of a monomeric phase of 5 at 90 K in the X-ray diffraction experiment.
Thermal and structural characterization of a series of homoleptic Cu(II) dialkyldithiocarbamate complexes: Bigger is only marginally better for potential MOCVD performance
Ngo, Silvana C.,Banger, Kulbinder K.,DelaRosa, Mark J.,Toscano, Paul J.,Welch, John T.
, p. 1575 - 1583 (2008/10/08)
A series of Cu(II) dialkyldithiocarbamate complexes, Cu(S2CNRR′)2, with R = R′ = n-Bu (1); i-Bu (2); c-Hex (3); CH2Ph (4); R = n-Bu, R′ = Et (5); R = n-Pr, R′ = c-PrCH2 (6); R = R′ = n-Pr (7); i-Pr (8); allyl (9), were prepared. The thermal properties of the complexes were investigated to determine if their potential performance in chemical vapor deposition processes was affected by the nature of the peripheral substituents of the ancillary ligands. Modest gains in volatility were noted for 2 and 7 over the most often utilized complex with R = R′ = Et, while 1 and 8 had thermal parameters and stability comparable to this standard. Unsymmetrical substitution, such as in 5, also improved volatility, with some loss of stability for this particular compound. X-ray diffraction studies of complexes 1-6 suggested that long range Cu?S interactions in the solid-state have little bearing on the thermal properties of this class of Cu(II) complexes.
Electron Spin Resonance Study of Some Copper(II) Dithiocarbamates and their Mixed-ligand Complexes
Newton, William J.,Tabner, Brian J.
, p. 466 - 471 (2007/10/02)
The e.s.r. spectra of seven copper(II) dithiocarbamates have been recorded in chloroform-ethanol mixtures at room temperature and at 113 K.It has been found that the addition of a range of salts to these dithiocarbamates destroys the complex forming a mixed-ligand complex, , with a new e.s.r. spectrum.When X is Cl or Br the additional interaction of the unpaired electron with a single halogen nucleus is observed.The complex forms a dipole-dipole coupled dimer and a computer simulation of the ΔMs = 2 absorption of this dimer has been obtained.
