- Synthesis and evaluation of new 1,3,4-thiadiazole derivatives as potent antifungal agents
-
With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (3a–3l) were synthesized and characterized. Due to thione-thiol tautomerism in the intermediate compound 2, type of subst
- Karaburun, Ahmet ?agr?,?evik, Ulviye Acar,Osmaniye, Derya,Sagl?k, Begüm Nurpelin,?avu?oglu, Betül Kaya,Levent, Serkan,?zkay, Yusuf,Koparal, Ali Sava?,Beh?et, Mustafa,As?m Kaplanc?kl?, Zafer
-
-
Read Online
- Synthesis and antifungal activities of ω-(5-arylamino-1,3,4-thiadiazol-2-thio)-ω(1H-1,2,4-triazol-1-yl) acetophenones
-
Several ω-(5-arylamino-1,3,4-thiadiazol-2-thiol)-ω-(1H-1,2,4-triazol-1- yl)acetophenones 4a-i have been synthesized. The representative compounds exhibit some antifungal and plant growth regulatory activities. The structures of these compounds have been confirmed by elemental analyses, 1H NMR, IR and MS spectra.
- Chu, Chang-Hu,Hui, Xin-Ping,Xu, Peng-Fei,Zhang, Zi-Yi,Li, Zhi-Chun,Liao, Ren-An
-
p. 2436 - 2438
(2007/10/03)
-
- an interesting isomerization: synthesis of mesoionic 5-arylamino-1,3,4-thiadiazolium-2-thiolates by using ω-bromo-ω-(1H-1,2,4-triazol-1-yl)acetophenone as catalyst
-
Mesoionic 5-arylamino-1,3,4-thiadiazolium-2-thiolates 7a-f were prepared by the isomerization of 5-arylamino-1,3,4-thiadiazol-2-thiones 5a-f by using ω-bromo-ω-(1H-1,2,4-triazol-1-yl)acetophenone 6 as catalyst. All the structures of mesoionic synthesized were confirmed by elemental analyses, 1H NMR, IR and MS spectral data. We have also determined the x-ray photoelectron spectroscopy (XPS) of the mesoionic and their precursors. A comparison of XPS spectra between the mesoionic and their precursors showed that the charge separation in mesoionic is distinctly larger than in their precursors.
- Chu, Chang-Hu,Hui, Xin-Ping,Xu, Peng-Fei,Zhang, Zi-Yi,Li, Zhi-Chun,Liao, Ren-An
-
p. 943 - 946
(2007/10/03)
-
- Alkali catalyzed thermal cyclization of 1-substituted and 1,6-disubstituted 2,5-dithiobiureas: Formation of 1,2,4-triazolidine-3,5-dithiones and/or 1,3,4-thiadiazoline-5-thiones
-
Alkali catalyzed thermal cyclization of 1-alkyl and 1,6-dialkyl-2,5-dithiobiureas (I, R=alkyl, R'=H and R=R'=alkyl) results in the formation of 4-alkyl-1,2,4-triazolidine-3,5-dithiones (V) (alkyl=Me or Et) and 2-alkylamino-Δ2-1,3,4-thiadiazoline-5-thiones (VI) (alkyl=n-Pr or n-Bu).Under the same conditions, 1-alkyl-6-aryl-2,5-dithiobiureas (I, R=alkyl, R'=aryl) give 2-arylamino-Δ2-1,3,4-thiadiazoline-5-thiones (IX) (alkyl=Me, Et, n-Pr or n-Bu) and 4-alkyl-1,2,4-triazolidine-3,5-dithiones (V) also when the alkyl groups are Me or Et.
- Raphael, Elsamma,Joshua, C. P.,Koshy, Lisamma
-
p. 635 - 638
(2007/10/02)
-
