- Synthesis method of o-trifluoromethyl methyl benzoate, m-trifluoromethyl methyl benzoate and p-trifluoromethyl methyl benzoate
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The invention provides a synthesis method of o-trifluoromethyl methyl benzoate, m-trifluoromethyl methyl benzoate and p-trifluoromethyl methyl benzoate. The synthesis method comprises the following steps: taking methyl benzoic acid as a raw material, carrying out acylating chlorination to obtain methylbenzoyl chloride, carrying out side-chain chlorination to obtain trichloromethyl benzoyl chloride, carrying out fluorination substitution to obtain trifluoromethyl benzoyl fluoride, and carrying out esterification to obtain a final product which is trifluoromethyl methyl benzoate. The synthesis method can be used for producing the o-trifluoromethyl methyl benzoate, the m-trifluoromethyl methyl benzoate and the p-trifluoromethyl methyl benzoate, is easily available in raw material, mild in reaction mechanism, high in reaction yield, few in reaction by-products, low in yield of three wastes and easy in treatment of three wastes, and is suitable for industrial production.
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Paragraph 0017
(2018/03/01)
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- A O-between the - trifluoromethyl benzoic acid to synthetic method (by machine translation)
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The present invention provides a O-between the - trifluoromethyl benzoic acid to the synthesis method, the method comprises the following steps: (1) between adjacent to methyl benzoic acid acylated preparation between neighbour methyl benzoyl chloride; (2) between the adjacent methyl benzoyl chloride to chlorine light between neighbour trichloromethyl benzoyl chloride is obtained; (3) adjacent to the trichloromethyl benzoyl chloride fluoride obtained between between neighbour trifluoromethyl methyl benzoyle fluoride; (4) adjacent to the trifluoromethyl benzoyle fluoride hydrolysis between the final product is obtained between neighbour trifluoromethyl methyl benzoic acid. The method of the invention cheap raw material, the product yield is high, the process is simple, is favorable for industrial production. (by machine translation)
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- Preparation of substituted benzotrichlorides
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A process for chlorinating a compound of the formula STR1 in which R1 is a C1 -alkyl radical, C1 -alkoxy radical or C1 -thioalkyl radical, and X1, X2, X3 and X4 are identical or different hydrogen or halogen, and X3 may alternatively be STR2 or --NCO, comprising, in an initial phase, dissolving a chlorination catalyst in the compound to be chlorinated, continuously metering this solution together with chlorine into a reaction vessel containing the compound to be chlorinated, and, after the initial phase, removing partially or fully chlorinated compounds from the reaction vessel, dissolving fresh chlorination catalyst in the removed compounds, and feeding this catalyst solution, together with chlorine, to the reaction vessel.
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- SOLUBILITY OF CHLORINE AND HYDROGEN CHLORIDE IN p-TOLUOYL CHLORIDE AND IN THE PRODUCTS OF ITS CHLORINATION IN THE SIDE CHAIN.
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In view of the absence of literature data on solubilities of chlorine and hydrogen chloride in the system under consideration and the need to have such data for determination of the kinetic parameters of the chlorination reaction, the authors studied the solubility of chlorine and hydrogen chloride in p-toluoyl chloride and in the products of its chlorination in the side chain (chloro-, dichloro-, and trichloromethylbenzoyl chlorides). The results of this investigation show that the solubilities of chlorine and hydrogen chloride in acyl chlorides depend appreciably on temperature and less on the nature of the compounds. Determination of the dependence of solubility of chlorine in p-toluoyl chloride at 40 degree on the partial pressure of chlorine in the gas phase gave a linear relationship, indicating that the system obeys Henry's law.
- Korotkii,Alymova,Uspenskaya,Emel'yanov,Motsarev
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p. 1095 - 1097
(2007/10/02)
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