148546-78-5

Basic information

• Product Name: 1-(5-AMINO-2-METHOXYPHENYL)-4-METHYLPIPERAZINE
• Synonyms: 1-(5-AMINO-2-METHOXYPHENYL)-4-METHYLPIPERAZINE;BenzenaMine, 4-Methoxy-3-(4-Methyl-1-piperazinyl)-;4-methoxy-3-(4-methyl-1-piperazinyl )-Benzenamine
• CAS NO: 148546-78-5
• Molecular Formula: C₁₂H₁₉N₃O
• Molecular Weight: 221.3
• Mol File: 148546-78-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(5-AMINO-2-METHOXYPHENYL)-4-METHYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-AMINO-2-METHOXYPHENYL)-4-METHYLPIPERAZINE(148546-78-5)
• EPA Substance Registry System: 1-(5-AMINO-2-METHOXYPHENYL)-4-METHYLPIPERAZINE(148546-78-5)

Safety Data

• Hazardous Substances Data: 148546-78-5(Hazardous Substances Data)

Usage

Molecular structure

Piperazine derivative with an amino group and a methoxy group attached to a phenyl ring, and a methyl group attached to the piperazine ring.

Field of application

Medicinal chemistry

Pharmaceutical potential

Development of new drugs targeting various biological pathways

Role in synthesis

Valuable building block in the synthesis of novel pharmaceutical compounds for the treatment of various diseases and disorders

Research significance

Studied for its potential as an inhibitor or modulator of specific biological processes

Importance in pharmacology

Contributes to drug discovery and understanding of biological pathways

Upstream product

• 109-01-3 1-methyl-piperazine 
• 91-16-7 1,2-dimethoxybenzene 
• 24812-90-6 methyl 3-amino-4-methoxybenzoate 
• 148547-51-7 N-methyl-N'-(2-methoxyphenyl)-piperazine 
• 148547-50-6 1-(2-Methoxy-5-nitro-phenyl)-4-methyl-piperazine 
• 148672-70-2 4-Methoxy-3-(4-methyl-piperazin-1-yl)-benzoic acid methyl ester 
• 55-86-7 mechlorethamine hydrochloride 

Downstream Products

• 209480-36-4 N-[4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl]-2-thiophenesulfonamide 
• 215162-65-5 5-bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]naphth-1-ylacetamide 
• 177488-09-4 N-[4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-(p-methoxyphenyl)piperazin-1-ylamide fumarate 
• 1325188-73-5 1-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)pyrrolidine-2,5-dione 
• 1325188-71-3 1-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)pyrrolidin-2-one 
• 1325190-12-2 C₁₆H₂₃N₃O₄ 

Relevant articles and documents

5-HT RECEPTOR MODULATORS

The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor IB (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

5-HT RECEPTOR MODULATORS

The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor 1B (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and componnds and compositions etc. for their treatment

Synthesis of potent and selective serotonin 5-HT1B receptor ligands

A series of serotonin 5-HT1B ligands were synthesized and evaluated for their potency and selectivity against other 5-HT receptor subtypes. Many of these new compounds displayed high affinity and selectivity for the 5-HT1B receptor a

PIPERAZIDES DERIVED FROM ARYLPIPERAZINE, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

Novel 5HT receptor antagonists of general formula (I) STR1 in which Ar 1 and Ar 2 are aromatic residues, X is O, NH, CH 2 O, or CH 2 NH, and R 1 is hydrogen or linear or branched alkyl comprising 1-6 carbon atoms, as well as their salts, hydrates, solvate