149401-02-5

Basic information

• Product Name: 1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine
• Synonyms: 1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine;4-Piperidinamine, 1-[[4-(trifluoromethyl)phenyl]methyl]-
• CAS NO: 149401-02-5
• Molecular Formula: C₁₃H₁₇F₃N₂
• Molecular Weight: 258
• Mol File: 149401-02-5.mol

Chemical Properties

• Boiling Point: 293.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.190±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.09±0.20(Predicted)
• CAS DataBase Reference: 1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine(149401-02-5)
• EPA Substance Registry System: 1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine(149401-02-5)

Safety Data

• Hazardous Substances Data: 149401-02-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine is used as a building block for the development of new drugs due to its potential pharmacological activity and the presence of the piperidine moiety, which is a common structural motif in many biologically active compounds.
Used in Medicinal Chemistry Research:
1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine is used as a target for drug discovery research because the trifluoromethyl group can impart certain desirable properties to the compound, such as increased lipophilicity or metabolic stability, enhancing its potential as a candidate for the development of new pharmaceuticals.
Used in Organic Synthesis:
1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine is used as a chemical intermediate in organic synthesis, where its unique structure and functional groups can be utilized to create a variety of complex organic compounds for various applications.

Upstream product

• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 
• 39546-32-2 4-carboxamidopiperidine 
• 1057266-16-6 1-(4-trifluoromethylbenzyl)-4-piperidone oxime 
• 939-99-1 4-trifluoromethylbenzyl chloride 
• 380424-34-0 1-(4-trifluoromethylbenzyl)piperidine-4-carboxamide 

Downstream Products

• 380426-29-9 2-chloro-6-[4-(1-(4-trifluoromethylbenzyl))piperidinylamino]-9-cyclopentylpurine 

Relevant articles and documents

TEAD INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation

A novel series of hybrid molecules were designed and synthesized by fusing the pharmacophoric features of cholinesterase inhibitor donepezil and diarylthiazole as potential multitarget-directed ligands for the treatment of Alzheimer's disease (AD). The compounds showed significant in vitro anticholinesterase (anti-ChE) activity, the most potent compound (44) among them showing the highest activity (IC50 value of 0.30 ± 0.01 μM) for AChE and (1.84 ± 0.03 μM) for BuChE. Compound 44 showed mixed inhibition of AChE in the enzyme kinetic studies. Some compounds exhibited moderate to high inhibition of AChE-induced Aβ1-42 aggregation and noticeable in vitro antioxidant and antiapoptotic properties. Compound 44 showed significant in vivo anti-ChE and antioxidant activities. Furthermore, compound 44 demonstrated in vivo neuroprotection by decreasing Aβ1-42-induced toxicity by attenuating abnormal levels of Aβ1-42, p-Tau, cleaved caspase-3, and cleaved PARP proteins. Compound 44 exhibited good oral absorption and was well tolerated up to 2000 mg/kg, po, dose without showing toxic effects.

The design and synthesis of purine inhibitors of CDK2. III

Cyclin-dependent kinases (CDKs) belong to a class of enzymes that control the ability of a cell to enter into and proceed through the cell division cycle. Using purine as a scaffold, we have synthesized a number of nanomolar inhibitors of CDK-2/cyclin E. In this report, the synthesis of a series of piperidine-substituted purine analogs will be presented, as well as some of their in vitro and in vivo biological effects.