- Method for synthesizing amorolfine drug intermediate p-tert-amyl benzyl bromide
-
A method for synthesizing an amorolfine drug intermediate p-tert-amyl benzyl bromide includes the following steps that 0.71 mol of tertiary amyl benzyl ammonium, 0.82-0.84 mol of bromoethane, 0.86 mol of cuprous bromide and 300 ml of oxalic acid solution
- -
-
Paragraph 0010-0011
(2017/03/08)
-
- Synthesis of new 7-benzofuranmethanamines as heterocyclic analogues of the squalenepoxidase-inhibitor Butenafine
-
Selected title compounds (6a-f, 7a-d) were synthesized by RedAl(R)-reduction of the carboxamides 4a-f and 5a-d, easily available from the corresponding (2,3-dihydro-)7-benzofurancarboxylic acids 1a-f or 2a-d, respectively. For practical reasons, the preparation of the 2,3-dihydro-2-methyl-7-benzofuranmethanamines 6h-k with varied N-substitution by alkylation of the N-methyl-benzofuranmethanamine 6g with preformed aralkylbromides 9a-d was preferred.
- Stanetty,Koller,Purstinger,Grubner
-
p. 351 - 358
(2007/10/02)
-