67467-96-3

Basic information

• Product Name: 2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propanal
• Synonyms: 2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propanal;2-methyl-3-(4-(tert-pentyl)phenyl)propanal;3-(4-tert-pentylphenyl)-2-methylpropanal
• CAS NO: 67467-96-3
• Molecular Formula: C₁₅H₂₂O
• Molecular Weight: 218.33
• EINECS: 604-604-1
• Mol File: 67467-96-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 295.3°C at 760 mmHg
• Flash Point: 130.3°C
• Appearance: /
• Density: 0.924g/cm³
• Vapor Pressure: 0.00153mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• Stability: Air Sensitive
• CAS DataBase Reference: 2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propanal(67467-96-3)
• EPA Substance Registry System: 2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propanal(67467-96-3)

Safety Data

• Hazardous Substances Data: 67467-96-3(Hazardous Substances Data)

Usage

Uses

4-(1,1-Dimethylpropyl)-α-methyl-benzenepropanal is an intermediate in the synthesis of trans-Amorolfine (A634165). trans-Amorolfine is an analog / impurity of Amorolfine (A634170, HCl); a morpholine antifungal drug and topical solution for the treatment of toenail infections.

InChI:InChI=1/C15H22O/c1-5-15(3,4)14-8-6-13(7-9-14)10-12(2)11-16/h6-9,11-12H,5,10H2,1-4H3

Upstream product

• 28162-11-0 1-chloromethyl-4-tert-pentylbenzene 
• 7020-81-7 N-(propylidene)-tert-butylamine 
• 7138-58-1 N-ethylideneaniline 
• 149530-71-2 1-Brommethyl-4-(1,1-dimethylpropyl)-benzol 
• 860556-27-0 1-iodo-4-(tertpentyl)benzene 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 81164-53-6 α-methyl-allylidene diacetate 
• 2049-95-8 tery-amylbenzene 

Downstream Products

• 78613-38-4 amorolfine hydrochloride 
• 67467-82-7 1-[3-(p-tert-amyl-phenyl)-2-methyl-propyl]-piperidine 
• 288583-04-0 4-[3-[p-(1,1-dimethylpropyl)-phenyl]-2-methylpropyl]-2,6-dimethylmorpholine 

Relevant articles and documents

Synthesis method of 2-methyl-3-(4-tert-amylphenyl) propanol

The invention discloses a synthesis method of 2-methyl-3-(4-tert-amylphenyl) propanol, which specifically comprises the following steps: 1, reacting propionaldehyde with primary amine R1-NH2 in the presence of a dehydrating agent to generate a compound A;

An efficient TiCl4-catalysed method for the synthesis of para-substituted aromatic aldehydes

An efficient and highly selective synthesis of para-substituted aromatic aldehydes has been achieved by TiCl4-catalysed Friedel-Crafts alkylation of monosubstituted benzenes with methacrolein diacetyl acetal.

Piperidines morpholines, etc., and fungicidal compositions thereof

Heterocyclic compounds characterized by the formula STR1 wherein R, R1, R2, R3, R4, R5, R6, X and z are as hereinafter set forth, prepared, inter alia, by reacting a compound characterized by the formula STR2 with an amine characterized by the formula STR3 wherein R, R1, R2, R3, R4, R5, R6, X and Y are as hereinafter set forth, are described. The end products are useful as fungicidal agents.