67467-96-3

Usage

Uses

Used in Pharmaceutical Industry:
2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propanal is used as an intermediate in the synthesis of trans-Amorolfine (A634165), which is an analog/impurity of Amorolfine (A634170, HCl). Amorolfine is a morpholine antifungal drug commonly used in the treatment of toenail infections. 2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propanal plays a crucial role in the development of effective antifungal medications, contributing to the fight against fungal infections.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propanal can be utilized as a building block for the creation of more complex molecules with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science. Its unique structure allows for further functionalization and modification, enabling the development of novel compounds with specific properties and functions.

InChI:InChI=1/C15H22O/c1-5-15(3,4)14-8-6-13(7-9-14)10-12(2)11-16/h6-9,11-12H,5,10H2,1-4H3

Upstream product

• 860556-27-0 1-iodo-4-(tertpentyl)benzene 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 28162-11-0 1-chloromethyl-4-tert-pentylbenzene 
• 7020-81-7 N-(propylidene)-tert-butylamine 
• 7138-58-1 N-ethylideneaniline 
• 149530-71-2 1-Brommethyl-4-(1,1-dimethylpropyl)-benzol 
• 81164-53-6 α-methyl-allylidene diacetate 
• 2049-95-8 tery-amylbenzene 

Downstream Products

• 67467-82-7 1-[3-(p-tert-amyl-phenyl)-2-methyl-propyl]-piperidine 
• 288583-04-0 4-[3-[p-(1,1-dimethylpropyl)-phenyl]-2-methylpropyl]-2,6-dimethylmorpholine 
• 78613-38-4 amorolfine hydrochloride 

Relevant academic research and scientific papers

Synthesis method of 2-methyl-3-(4-tert-amylphenyl) propanol

The invention discloses a synthesis method of 2-methyl-3-(4-tert-amylphenyl) propanol, which specifically comprises the following steps: 1, reacting propionaldehyde with primary amine R1-NH2 in the presence of a dehydrating agent to generate a compound A;

Betti's base for crystallization-induced deracemization of substituted aldehydes: synthesis of enantiopure amorolfine and fenpropimorph

The acid-promoted crystallization-induced diastereoisomer transformation (CIDT) of naphthoxazines derived from racemic O-protected 2-substituted 4-hydroxybutyraldehydes and enantiopure Betti's base allows the deracemization of the starting aldehydes with ee up to 96%. As an alternative, reduction with lithium aluminum hydride of the diastereoisomerically enriched naphthoxazines leads to enantioenriched primary amines. The utility of the latter strategy was demonstrated by applying it to the synthesis of enantioenriched fenpropimorph and to the first synthesis of enantiopure amorolfine, with ee up to 99.5%.

An efficient TiCl4-catalysed method for the synthesis of para-substituted aromatic aldehydes

An efficient and highly selective synthesis of para-substituted aromatic aldehydes has been achieved by TiCl4-catalysed Friedel-Crafts alkylation of monosubstituted benzenes with methacrolein diacetyl acetal.

Process for producing 3-[4-(1,1-dimethyl-propyl)-phenyl]2-methyl-propionaldehyde and cis-4{3-[4-(1,1-dimethyl-propyl)-phenyl]2-methyl-propyl}-2,6-dimethyl-morpholine (amorolfine)

The present invention discloses a new process for the preparation of 3-[4-(1,1-dimethyl-propyl)-phenyl]-2-methyl-propionaldehyde and for the preparation of cis-4-{3-[4-(1,1-dimethyl-propyl)-phenyl]-2-methyl-propyl}-2,6-dimethyl-morpholine (Amorolfine).

Piperidines morpholines, etc., and fungicidal compositions thereof

Heterocyclic compounds characterized by the formula STR1 wherein R, R1, R2, R3, R4, R5, R6, X and z are as hereinafter set forth, prepared, inter alia, by reacting a compound characterized by the formula STR2 with an amine characterized by the formula STR3 wherein R, R1, R2, R3, R4, R5, R6, X and Y are as hereinafter set forth, are described. The end products are useful as fungicidal agents.